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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica 期刊论文 JOURNAL OF NATURAL PRODUCTS, 2021, 卷号: 84, 期号: 8, 页码: 2111-2120 作者:  Chen, Jian-Jun;  Bai, Wei;  Lu, Yu-Bo;  Feng, Zi-Yun;  Gao, Kun 收藏  |  浏览/下载：31/0  |  提交时间：2021/11/04 Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13 作者:  Huang, He-ming;  Fan, Shi-jie;  Zhou, Xiao-ru;  Liu, Yan-jun;  Li, Xiao 收藏  |  浏览/下载：58/0  |  提交时间：2021/11/04 nonalcoholic steatohepatitis  inflammation  histone deacetylase inhibitor  givinostat  epigenetics   Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Zhou, Yu-bo;  Zhang, Yang-ming;  Huang, Hong-hui;  Shen, Li-jing;  Han, Xiao-feng 收藏  |  浏览/下载：93/0  |  提交时间：2021/11/04 multiple myeloma  HDAC inhibitor  bisthianostat  pharmacodynamics  pharmacokinetics  phase 1a clinical trial  antitumor drug   Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution 期刊论文 CELL REPORTS, 2021, 卷号: 36, 期号: 4, 页码: 22 作者:  Gao, Mengqing;  Wang, Jin;  Rousseaux, Sophie;  Tan, Minjia;  Pan, Lulu 收藏  |  浏览/下载：67/0  |  提交时间：2021/11/04 Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7 作者:  Wang, Yi;  Fang, Sui;  Wu, Yan;  Cheng, Xi;  Zhang, Lei-ke 收藏  |  浏览/下载：103/0  |  提交时间：2021/08/17 SARS-CoV-2  envelope protein (2-E)  cation channel  high-throughput screening (HTS)  anti-virus   Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13 作者:  Gao, Feng;  Chen, Xiaoxu;  Lu, Junyan;  Hu, Shulei;  Xu, Hui 收藏  |  浏览/下载：42/0  |  提交时间：2021/05/24 Ceramide analogs  AKT inhibitor  MK2206  Colon cancer  Combination therapy   Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Jiang, Kai-long;  Tong, Le-xian;  Wang, Tao;  Wang, Han-lin;  Hu, Xiao-bei 收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24 CHK1 inhibitors  PY34  drug sensitivity  c-Myc  hematologic malignancies   A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia 期刊论文 Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1 作者:  Xiao,Shifu;  Chan,Piu;  Wang,Tao;  Hong,Zhen;  Wang,Shuzhen 收藏  |  浏览/下载：148/0  |  提交时间：2021/05/24 Sodium oligomannate  Efficacy  Safety  Alzheimer’s disease  Clinical trial   Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 31, 页码: 4 作者:  Xiang, Hao-Yue;  Chen, Jian-Yang;  Huan, Xia-Juan;  Chen, Yi;  Gao, Zhao-bing 收藏  |  浏览/下载：14/0  |  提交时间：2021/05/24 Antiproliferative  Cancer  PARP inhibitors  Pyrrolo[12-b]pyridazine   Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10 作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun 收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24 PI3K  Pyrrolo[2,1-f][1,2,4]triazine  Anti-cancer  Target therapy