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浏览/检索结果: 共6条，第1-6条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10 作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun 收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24 PI3K  Pyrrolo[2,1-f][1,2,4]triazine  Anti-cancer  Target therapy   Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4 作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian 收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 Antiproliferative  Cancer  Therapy  PI3K inhibitors  Pyrrolo [2,1-f][1,2,4] triazine  Kinase   Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: [db:dc_citation_issue], 页码: 1429-1440 作者:  Xin, Minhang;  Zhang, Liandi;  Tang, Feng;  Tu, Chongxing;  Wen, Jun 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/03 Novel  Hedgehog signaling pathway  Pyrrolo[2,1-f][1,2,4]triazine  Inhibitors   Copper(II)-catalyzed cascade approach for the synthesis of pyrrolo[2,1-f][1,2,4]triazine-fused isoquinolines 期刊论文 RSC ADVANCES, 2014, 卷号: 4, 期号: 22, 页码: 11168-11175 作者:  Chen, Jianyang;  Liu, Bo;  Chen, Yanhong;  He, Qian;  Yang, Chunhao 收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 Privileged Scaffolds or Promiscuous Binders: A Glance of Pyrrolo[2,1-f][1,2,4]triazines and Related Bridgehead Nitrogen Heterocycles in Medicinal Chemistry 期刊论文 CURRENT PHARMACEUTICAL DESIGN, 2013, 卷号: 19, 期号: 8, 页码: 1528-1548 作者:  Song, Yu'ning;  Zhan, Peng;  Zhang, Qingzhu;  Liu, Xinyong 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/23 Heterocycle  Bridgehead nitrogen heterocycle  Privileged scaffold  Bioisosters  Pyrrolo[2,1-f][1,2,4]triazine  Biological activities  Drug  design   Studies of chirality effect of 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine on p38 alpha by molecular dynamics simulations and free energy calculations 期刊论文 Journal of computer-aided molecular design, 2009, 卷号: 23, 期号: 10, 页码: 737-745 作者:  Chen, Quan;  Cui, Wei;  Ji, Mingjuan 收藏  |  浏览/下载：28/0  |  提交时间：2019/05/10 P38 alpha  Molecular dynamics simulation  Binding free energy  Chirality  Inhibitor