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Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities
期刊论文
BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7
作者:
Li, Yan-He
;
Yang, Sui-Qun
;
Li, Xiao-Ming
;
Li, Xin
;
Wang, Bin-Gui
收藏
  |  
浏览/下载:215/0
  |  
提交时间:2023/01/06
Macrolides
Penicillium cyclopium
Deep-sea sediment
Cytotoxicity
Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Xu, Changzhi
;
Zhang, Lanlan
;
He, Huimin
;
Liu, Xiaoyi
;
Pei, Xinxin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
sheep tail fat
non-small-cell lung cancer
heptadecanoic acid
antiproliferative effect
Akt
S6K signaling pathway
Dammarane Triterpenoids with Rare Skeletons from Gynostemma pentaphyllum and Their Cytotoxic Activities
期刊论文
Fitoterapia, 2022, 期号: 162, 页码: 105280
作者:
Jun Wang
;
Xian-Hua Meng
;
Wei-Feng Wang
;
Chun-Yan Sang
;
Thi-Kim-Quy Ha
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/11/30
Gynostemma pentaphyllum (Thunb.) Makino
Cucurbitaceae
Triterpenes, cytotoxic activities
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
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  |  
浏览/下载:28/0
  |  
提交时间:2021/12/16
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/01/04
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
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  |  
浏览/下载:15/0
  |  
提交时间:2021/12/16
Clerodenoids A-F: C-ring Aromatized and/or Rearranged Abietane Diterpenoids from Clerodendrum chinense var. simplex
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2021, 页码: 7
作者:
Qi, Jingjing
;
Zhang, Yan
;
Liu, Qunfang
;
Liu, Hongchun
;
Fan, Yaoyue
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/08/17
Clerodendrum chinense
Natural products
Diterpenoids
Structural elucidation
Antiproliferative activities
In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics
期刊论文
CHEMICAL COMMUNICATIONS, 2021, 页码: 4
作者:
Steinbrueck, Axel
;
Sedgwick, Adam C.
;
Han, Hai-Hao
;
Zhao, Michael Y.
;
Sen, Sajal
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/06/11
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
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