Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica

doi:10.1021/acs.jnatprod.1c00096

	Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica
	Chen, Jian-Jun 1; Bai, Wei 1; Lu, Yu-Bo 1; Feng, Zi-Yun 1; Gao, Kun 1; Yue, Jian-Min 1,2,3
刊名	JOURNAL OF NATURAL PRODUCTS
	2021-08-27
卷号	84 期号:8 页码:2111-2120
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.1c00096
通讯作者	Gao, Kun(npchem@lzu.edu.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	A bioactivity-guided study on the leaves of Picrasma javanica led to the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were elucidated by a combination of spectroscopic data analysis, X-ray crystallography studies, and electronic circular dichroism (ECD) data interpretation. Compounds 1-7 are rare examples of quassinoids with a keto carbonyl group at C-12. The biological activities of 11 of the more abundant isolates were evaluated against five phytopathogenic fungi in vitro, and several of them including 6 and 15 showed moderate inhibitory effects that were comparative to those of the positive control, carbendazim. In addition, the preliminary structure-activity relationships (SARs) of these quassinoids were also investigated.
资助项目	National Natural Science Foundation of China[81973193] ; Natural Science Foundation of Gansu[20JR5RA279] ; Funda-mental Research Funds for the Central Universities[lzujbky2019-ct03]
WOS关键词	ANTIFUNGAL ACTIVITIES ; CONSTITUENTS ; GLUCOSIDES ; BARK
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000692038100006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297774]
专题	中国科学院上海药物研究所
通讯作者	Gao, Kun; Yue, Jian-Min
作者单位	1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Jian-Jun,Bai, Wei,Lu, Yu-Bo,et al. Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(8):2111-2120.
APA	Chen, Jian-Jun,Bai, Wei,Lu, Yu-Bo,Feng, Zi-Yun,Gao, Kun,&Yue, Jian-Min.(2021).Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica.JOURNAL OF NATURAL PRODUCTS,84(8),2111-2120.
MLA	Chen, Jian-Jun,et al."Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica".JOURNAL OF NATURAL PRODUCTS 84.8(2021):2111-2120.