CORC

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CORC

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：20/0  |  提交时间：2022/01/04
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:  Jiang, Kai-long;  Tong, Le-xian;  Wang, Tao;  Wang, Han-lin;  Hu, Xiao-bei
收藏  |  浏览/下载：49/0  |  提交时间：2021/05/24
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao
收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:  Gao, Yang;  Wen, Pengbo;  Chen, Bin;  Hu, Guanshuo;  Wu, Lijun
收藏  |  浏览/下载：49/0  |  提交时间：2020/11/30
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment 期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:  Zhang, Jinhua;  Si, Jing;  Gan, Lu;  Zhou, Rong;  Guo, Menghuan
收藏  |  浏览/下载：24/0  |  提交时间：2022/01/12
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2018, 卷号: 76, 页码: 53-60
作者:  Li, Yaping;  Peng, Jiale;  Zhou, Yeheng;  Li, Penghua;  Li, Yingying
收藏  |  浏览/下载：29/0  |  提交时间：2018/11/12
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang
收藏  |  浏览/下载：109/0  |  提交时间：2018/07/16
RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells 期刊论文
Clinical Cancer Research, 2018, 卷号: 24, 期号: 7, 页码: 1629-1643
作者:  Shanhuai Ma;  Pengyan Fa;  Zhefu Ma;  Hongbing Wang;  Yao Zhang
收藏  |  浏览/下载：35/0  |  提交时间：2018/09/28
Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors 期刊论文
CANCER LETTERS, 2017, 卷号: 392
作者:  Zhang, Ming;  Singh, Ratnakar;  Peng, Shaohua;  Mazumdar, Tuhina;  Sambandam, Vaishnavi
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05

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