Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment

doi:10.1002/jcp.29960

	Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment
	Zhang, Jinhua 1,2,3; Si, Jing 1,2,3; Gan, Lu 1,2,3; Zhou, Rong 4; Guo, Menghuan 5; Zhang, Hong 1,2,3
刊名	JOURNAL OF CELLULAR PHYSIOLOGY
	2020-07-20
页码	17
关键词	DNA damage DNA repair particle therapy photon therapy radiosensitizer
ISSN号	0021-9541
DOI	10.1002/jcp.29960
通讯作者	Si, Jing(sijing@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要	Radiotherapy is one of the major modalities for malignancy treatment. High linear energy transfer (LET) charged-particle beams, like proton and carbon ions, exhibit favourable depth-dose distributions and radiobiological enhancement over conventional low-LET photon irradiation, thereby marking a new era in high precision medicine. Tumour cells have developed multicomponent signal transduction networks known as DNA damage responses (DDRs), which initiate cell-cycle checkpoints and induce double-strand break (DSB) repairs in the nucleus by nonhomologous end joining or homologous recombination pathways, to manage ionising radiation (IR)-induced DNA lesions. DNA damage induction and DSB repair pathways are reportedly dependent on the quality of radiation delivered. In this review, we summarise various types of DNA lesion and DSB repair mechanisms, upon irradiation with low and high-LET radiation, respectively. We also analyse factors influencing DNA repair efficiency. Inhibition of DNA damage repair pathways and dysfunctional cell-cycle checkpoint sensitises tumour cells to IR. Radio-sensitising agents, including DNA-PK inhibitors, Rad51 inhibitors, PARP inhibitors, ATM/ATR inhibitors, chk1 inhibitors, wee1 kinase inhibitors, Hsp90 inhibitors, and PI3K/AKT/mTOR inhibitors have been found to enhance cell killing by IR through interference with DDRs, cell-cycle arrest, or other cellular processes. The cotreatment of these inhibitors with IR may represent a promising therapeutic strategy for cancer.
资助项目	National Key R&D Program of China[2018YFE0205100] ; Science and Technology Plan Project of Chengguan district, Lanzhou[2019RCCX0071] ; Lanzhou Talent Innovation and Entrepreneurship Project[2019-RC-76] ; Key Program of the National Natural Science Foundation of China[U1632270] ; CAS Light of West China Program[2018-6]
WOS关键词	SQUAMOUS-CELL CARCINOMA ; POLY(ADP-RIBOSE) POLYMERASE INHIBITOR ; DEPENDENT PROTEIN-KINASE ; DOUBLE-STRAND BREAKS ; HUMAN TUMOR-CELLS ; CARBON-ION-BEAMS ; HOMOLOGOUS RECOMBINATION REPAIR ; HUMAN GLIOBLASTOMA CELLS ; INDUCED DNA-DAMAGE ; STEM-LIKE CELLS
WOS研究方向	Cell Biology ; Physiology
语种	英语
出版者	WILEY
WOS记录号	WOS:000550508600001
资助机构	National Key R&D Program of China ; Science and Technology Plan Project of Chengguan district, Lanzhou ; Lanzhou Talent Innovation and Entrepreneurship Project ; Key Program of the National Natural Science Foundation of China ; CAS Light of West China Program
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/140237]
专题	中国科学院近代物理研究所
通讯作者	Si, Jing; Zhang, Hong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 4.Minist Ecol & Environm Peoples Republ China, Nanjing Inst Environm Sci, Res Ctr Ecol Impacts & Environm Hlth Effects Tox, Nanjing, Jiangsu, Peoples R China 5.Lanzhou Univ, Sch Pharm, Lanzhou, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jinhua,Si, Jing,Gan, Lu,et al. Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2020:17.
APA	Zhang, Jinhua,Si, Jing,Gan, Lu,Zhou, Rong,Guo, Menghuan,&Zhang, Hong.(2020).Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment.JOURNAL OF CELLULAR PHYSIOLOGY,17.
MLA	Zhang, Jinhua,et al."Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment".JOURNAL OF CELLULAR PHYSIOLOGY (2020):17.