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上海药物研究所 [20]
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期刊论文 [52]
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leflunomideincreasedtherenalexposureofacyclovirbyinhibitingoat13andmrp2
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 1, 页码: 129
作者:
Liao Xiaoying
;
Deng Qiangqiang
;
Han Li
;
Wu Zhitao
;
Peng Zhaoliang
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
leflunomide
teriflunomide
acyclovir
organic anion transporter
multidrug resistance associated protein (MRP) 2
drugdrug interaction
pharmacokinetics
Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 1, 页码: 129-137
作者:
Liao, Xiao-ying
;
Deng, Qiang-qiang
;
Han, Li
;
Wu, Zhi-tao
;
Peng, Zhao-liang
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/01
leflunomide
teriflunomide
acyclovir
organic anion transporter
multidrug resistance associated protein (MRP) 2
drug-drug interaction
pharmacokinetics
Enhancement of cisplatin efficacy by lipid-CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment
期刊论文
BIOMATERIALS SCIENCE, 2019, 卷号: 7, 期号: 10, 页码: 4260-4272
作者:
He, Chuanchuan
;
Zhang, Xiaojuan
;
Yan, Ruicong
;
Zhao, Pengxuan
;
Chen, Yan
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  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Quercetin and kaempferol increase the intestinal absorption of isorhamnetin coexisting in Elaeagnus rhamnoides (L.) A. Nelson (Elaeagnaceae) extracts via regulating multidrug resistance-associated protein 2
期刊论文
PHYTOMEDICINE, 2019, 卷号: 53
作者:
Xiao Yi
;
Xin Lei
;
Li Lujia
;
Li Guowen
;
Shi Xiufeng
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  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
Isorhamnetin
Flavonoids
Intestinal absorption
Multidrug resistance-associated protein 2 (MRP2)
Elaeagnus rhamnoides (L.) A. nelson (elaeagnaceae)
Intra-herb interaction
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 17, 页码: 3486-3503
作者:
Dong, Jiajia
;
Olaleye, Olajide E.
;
Jiang, Rongrong
;
Li, Jing
;
Lu, Chuang
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  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor alpha Activation
期刊论文
MOLECULAR PHARMACOLOGY, 2018, 卷号: 93, 期号: 6, 页码: 563-574
作者:
Wang, Le
;
Ma, Leilei
;
Lin, Yunfei
;
Liu, Xing
;
Xiao, Ling
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  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
期刊论文
Drug Metabolism and Disposition, 2018
作者:
Danyi Lu
;
Dong Dong
;
Qian Xie
;
Zhijie Li
;
Baojian Wu
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/31
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats
期刊论文
Toxicology Letters, 2018, 卷号: Vol.295, 页码: 195-204
作者:
Shijie Wen
;
Changyuan Wang
;
Xiaokui Huo
;
Qiang Meng
;
Zhihao Liu
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/25
Vancomycin
JBP485
Nephrotoxicity
Transporter
Endogenous toxins
Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2018, 卷号: 16, 期号: 1, 页码: 20
作者:
Wang ZhenDong
;
Wang RuiZhi
;
Xia YuanZheng
;
Kong LingYi
;
Yang Lei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
CHEMOTHERAPEUTIC-AGENTS
HERBA-EPIMEDII
CANCER-CELLS
TRANSPORTERS
EXPRESSION
FLAVONOIDS
PROTEIN-1
ABCB1
PHARMACOKINETICS
PROLIFERATION
Osteosarcoma
Icaritin
Multidrug resistance
MDR1
MRP1
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