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Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients
期刊论文
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 页码: 13
作者:
Liu, Lu
;
Wang, Qian
;
Xie, Cen
;
Xi, Ning
;
Guo, Zitao
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
drug–
drug interaction
gefitinib
ningetinib
transporters
A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 252, 页码: 9
作者:
Cong, Jiaojiao
;
Ruan, Yiling
;
Lyu, Qinglin
;
Qin, Xiaohui
;
Qi, Xinming
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Aconitum alkaloids
Blood-brain barrier
Proton-coupled organic cation antiporter
hCMEC/D3 cells
Drug transport
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer
期刊论文
PHARMACOLOGICAL RESEARCH, 2019, 卷号: 147, 页码: 104387
作者:
Guo, Jianli
;
Wang, Qingling
;
Zhang, Yue
;
Sun, Wenhui
;
Zhang, Shuangzhe
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/12/02
Daidzein
Topotecan
Breast cancer
ER alpha
Drug resistance
Topoisomerase I
Hypoxia-inducible factor-2 alpha directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
期刊论文
MOLECULAR ONCOLOGY, 2019, 卷号: Vol.13 No.2, 页码: 403-421
作者:
He, Miao
;
Wu, Huizhe
;
Jiang, Qian
;
Liu, Yinuo
;
Han, Li
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/12/13
adriamycin
drug resistance
hypoxia
hypoxia-inducible factor-2 alpha
ovarian cancer stem cells
Hypoxia‐inducible factor‐2α directly promotes BCRP expression and mediates the resistance of ovarian cancer stem cells to adriamycin
期刊论文
Molecular Oncology, 2019, 卷号: Vol.13 No.2, 页码: 403-421
作者:
Miao He
;
Huizhe Wu
;
Qian Jiang
;
Yinuo Liu
;
Li Han
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  |  
浏览/下载:26/0
  |  
提交时间:2019/12/17
adriamycin
drug
resistance
hypoxia
hypoxia‐inducible
factor‐2α
ovarian
cancer
stem
cells
Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship
期刊论文
2019, 卷号: 61, 页码: 104642
作者:
Fan Xiaoqing
;
Bai Jie
;
Zhao Shengyu
;
Hu Minwan
;
Sun Yanhong
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/03
BCRP
Flavonoids
Inhibition
Molecular mechanism
Structure-activity relationships
Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor alpha Activation
期刊论文
MOLECULAR PHARMACOLOGY, 2018, 卷号: 93, 期号: 6, 页码: 563-574
作者:
Wang, Le
;
Ma, Leilei
;
Lin, Yunfei
;
Liu, Xing
;
Xiao, Ling
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
期刊论文
Drug Metabolism and Disposition, 2018
作者:
Danyi Lu
;
Dong Dong
;
Qian Xie
;
Zhijie Li
;
Baojian Wu
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/31
A fast screening model for drug permeability assessment based on native small intestinal extracellular matrix
期刊论文
RSC ADVANCES, 2018, 卷号: 8, 期号: 60, 页码: 34514-34524
作者:
Li, Na
;
Sui, Zhigang
;
Liu, Yong
;
Wang, Dandan
;
Ge, Guangbo
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/06/20
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
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