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中国科学院大学 [5]
昆明植物研究所 [4]
上海生物化学与细胞生... [4]
上海药物研究所 [3]
中南大学 [2]
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期刊论文 [20]
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Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3229-3236
作者:
Duan, Zhe
;
Liu, Jingqiu
;
Niu, Liping
;
Wang, Jun
;
Feng, Mingqian
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2020/07/01
IDH1 mutation
High-throughput screening
Pan-inhibitor
2-HG
Gliomas
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
期刊论文
CANCER CELL, 2019, 卷号: 35, 期号: 4, 页码: 677-+
作者:
Huang, Yue
;
Su, Rui
;
Sheng, Yue
;
Dong, Lei
;
Dong, Ze
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 502, 期号: 1, 页码: 110-115
作者:
Shen, Xing
;
Xing, Shuang
;
Zhang, Lu
;
Wang, Fangmin
;
Ou, Hongling
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/03/29
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis
期刊论文
CANCER LETTERS, 2018, 卷号: 431, 页码: 150-160
作者:
Zhang, Xiong
;
Zheng, Xingling
;
Yang, Hong
;
Yan, Juan
;
Fu, Xuhong
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
MLL leukemia
Piribedil
H3K4 methylation
Cell cycle
Apoptosis
Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation
期刊论文
CANCER RESEARCH, 2016, 卷号: 76, 期号: 9, 页码: 2698-2709
作者:
Yu, Zu-Yin
;
Xiao, He
;
Wang, Li-Mei
;
Shen, Xing
;
Jing, Yu
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2016/08/22
Targeting peroxiredoxin I potentiates 1,25-dihydroxyvitamin D3-induced cell differentiation in leukemia cells
期刊论文
MOLECULAR MEDICINE REPORTS, 2016, 卷号: 13, 期号: 3, 页码: 2201-2207
作者:
Wei, Wei
;
Liu, Chuanxu
;
Qin, Dongjun
;
Song, Lili
;
Xia, Li
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2016/06/27
adenanthin
1
25-dihydroxyvitamin D3
leukemia
peroxiredoxin I
cell differentiation
Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721
期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2012, 卷号: 50, 页码: 1962-1968
作者:
Wang, Li
;
Sun, Chao
;
Wang, Zhen-Hua
;
Guo, Guang-Qin
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2018/07/05
Ortho-topolin Riboside
Apoptosis
Akt
Erk1/2
Adenosine Kinase
Human Hepatoma Cell
Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.
期刊论文
PLOS ONE, 2011, 卷号: 6, 期号: 8, 页码: e23720
作者:
Zhu, Jian Feng*
;
Li, Zi Jian
;
sen Zhang, Guang
;
Meng, Kun
;
Kuang, Wen Yong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
Apoptosis,Cell differentiation,Bone marrow cells,Cell staining,Cancer treatment,Leukemia cells,Cell proliferation,Protein expression
Pharicin B stabilizes retinoic acid receptor-alpha and presents synergistic differentiation induction with ATRA in myeloid leukemic cells
期刊论文
BLOOD, 2010, 卷号: 116, 期号: 24, 页码: 5289-5297
作者:
Gu, Zhi-Min
;
Wu, Ying-Li
;
Zhou, Mei-Yi
;
Liu, Chuan-Xu
;
Xu, Han-Zhang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2015/08/17
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