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西安交通大学 [3]
上海药物研究所 [2]
昆明植物研究所 [2]
武汉大学 [2]
深圳先进技术研究院 [1]
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期刊论文 [9]
学位论文 [3]
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Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 卷号: 38, 期号: 4, 页码: 975-984
作者:
Xu, Heng
;
Tang, Zhengkuan
;
Zuo, Yu
;
Xiong, Fengmin
;
Chen, Kaixian
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
cIAP1
dimerization
conformational change
MD simulation
高温与低温驯化下皱纹盘鲍幼鲍耐热性的代谢组学与转录组学比较分析
学位论文
中国科学院海洋研究所: 中国科学院大学, 2019
作者:
高婷婷
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/06/11
皱纹盘鲍(Haliotis discus hannai Ino)
耐热性
代谢生理
代谢组
转录组
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
LCL161 Increases Paclitaxel-Induced Apoptosis by Degrading cIAP1 and cIAP2 in NSCLC
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2017, 卷号: 12, 页码: S925-S925
作者:
Yang, Chengcheng
;
Wang, Huangzhen
;
Zhang, Boxiang
;
Chen, Yimeng
;
Zhang, Yamin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/11/26
paclitaxel
NSCLC
LCL161
apoptosis
LCL161 increases paclitaxel- induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35, 期号: [db:dc_citation_issue]
作者:
Yang, Chengcheng
;
Wang, Huangzhen
;
Zhang, Boxiang
;
Chen, Yimeng
;
Zhang, Yamin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/02
Paclitaxel
NSCLC
LCL161
Apoptosis
cIAP
LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC.
期刊论文
Journal of experimental & clinical cancer research : CR, 2016, 卷号: 35, 页码: 158
作者:
Yang Chengcheng
;
Wang Huangzhen
;
Zhang Boxiang
;
Chen Yimeng
;
Zhang Yamin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/11/26
Apoptosis
NSCLC
cIAP
Paclitaxel
LCL161
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNF alpha and ROS production
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 4, 页码: 1995-2008
作者:
Yu, Xinfang
;
Deng, Qipan
;
Li, Wei
;
Xiao, Lanbo
;
Luo, Xiangjian
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2015/06/29
necoalbaconol
necroptosis
RIPK
TNF alpha
NF-kappa B signaling pathway
ROS
NF-κB信号通路抑制剂筛选及抗肿瘤机制研究
学位论文
博士, 北京: 中国科学院大学, 2013
作者:
苏佳
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  |  
浏览/下载:403/0
  |  
提交时间:2016/05/31
天然产物
抗肿瘤
NF-κB
作用靶点
微管
Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents
期刊论文
Journal of medicinal chemistry, 2012
作者:
Peng, Yuefeng
;
Sun, Haiying
;
Lu, Jianfeng
;
Liu, Liu
;
Cai, Qian
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2015/08/25
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