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Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 673
作者:  Lu, Qin;  He, Yuanming;  Wang, Yuehu;  Gao, Li;  Zheng, Yunjing
收藏  |  浏览/下载:33/0  |  提交时间:2018/07/30
Trans-cinnamaldehyde promotes nitric oxide release via the protein kinase-B/v-Akt murine thymoma viral oncogene -endothelial nitric oxide synthase pathway to alleviate hypertension in SHR. Cg-Lepr(cp)/NDmcr rats 期刊论文
JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2018, 卷号: 38, 页码: 548-555
作者:  Zhang Lu;  Wu Lili;  Liu Ximing;  Hisae, Yoshitomi;  Katsumi, Ikeda
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/19
Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:49/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
Apigenin inhibits pressure overload-induced cardiac hypertrophy 期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 卷号: 11, 期号: 4
作者:  Dong, Xuan;  Zhou, Heng;  Zhang, Yan;  Xu, Man;  Hao, Yarong
收藏  |  浏览/下载:12/0  |  提交时间:2019/12/05
Protective Effects the Akt Activator SC79 in Hepatic Ischemia-Reperfusion Injury 期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24, 页码: 4346-4354
作者:  Zhou, Hui;  Yu, Ying;  Zhang, Jinna;  Zhang, Yunfang;  Luan, Qi
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/11
SC79, the AKT Activator Protects Cerebral Ischemia in a Rat Model of Ischemia/Reperfusion Injury 期刊论文
MEDICAL SCIENCE MONITOR, 2018, 卷号: 24, 页码: 5391-5397
作者:  Luan, Qi;  Pan, Lixiao;  He, Dongyong;  Gong, Xingji;  Zhou, Hui
收藏  |  浏览/下载:7/0  |  提交时间:2019/12/11
Adenosine triphosphate-sensitive potassium channel opener protects PC12 cells against hypoxia-induced apoptosis through PI3K/Akt and Bcl-2 signaling pathways 期刊论文
NEURAL REGENERATION RESEARCH, 2010, 卷号: 5, 期号: 22, 页码: 1706-1711
作者:  Zhang Hong;  Jia Chunhong;  Zhao Danyang;  Lu Yang;  Wang Runling
收藏  |  浏览/下载:105/0  |  提交时间:2021/02/02
Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition 期刊论文
Toxicology in Vitro, 2009
作者:  Wang C;  Li S;  Wang MW.
收藏  |  浏览/下载:4/0  |  提交时间:2019/02/27
Anti-Inflammatory  Agents,  Non-Steroidal/*pharmacology  Antineoplastic  Agents  Biotransformation/drug  effects  Blotting,  Western  Caspases/*physiology  Cell  Death/drug  effects  Cell  Line,  Tumor  Cell  Survival  Coloring  Agents  Extracellular  Signal-Regulated  MAP  Kinases/antagonists  &  inhibitors/metabolism  Fas  Ligand  Protein/biosynthesis/*physiology  Humans  Melanoma,  Experimental/*drug  therapy/pathology  NF-kappa  B/antagonists  &  inhibitors/metabolism/*physiology  Oncogene  Protein  v-akt/*physiology  Phosphatidylinositol  3-Kinases/*physiology  Plant  Extracts/*pharmacology  Proteasome  Inhibitors  Proto-Oncogene  Proteins  c-bcl-2/metabolism  Quinazolines/*pharmacology  Signal  Transduction/drug  effects  Tetrazolium  Salts  Thiazoles  Ubiquitin/*antagonists  &  inhibitors  
Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis 期刊论文
ONCOGENE, 2004, 卷号: 23, 期号: 56, 页码: 9052-9061
作者:  Wei, L;  Yang, Y;  Zhang, X;  Yu, Q
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08


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