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上海药物研究所 [5]
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厦门大学 [4]
复旦大学上海医学院 [4]
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Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
收藏
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浏览/下载:85/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
乙型肝炎病毒HBx蛋白类BH3结构域肽段与Bcl-xL相互作用的结构与功能研究
学位论文
2017, 2016
张莹
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  |  
浏览/下载:2/0
  |  
提交时间:2017/06/20
乙肝病毒(HBV)
HBx
Bcl-xL
hepatitis B virus(HBV)
HBx
Bcl-xL
Pelota及p53上调凋亡控制因子的结构生物学研究
学位论文
2017, 2014
张兰君
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  |  
浏览/下载:3/0
  |  
提交时间:2017/06/20
结构生物学
X射线晶体学
分子置换法
pelota蛋白
结构生物学
人类
PUMA
Hsc70
促凋亡
structural biology
X-ray crystallography
molecular replacement
Pelota
structural biology
human
PUMA
BH3 domain
Apoptosis
Mimicking the BIM BH3 domain overcomes resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 65
作者:
Xia, Jinjing
;
Bai, Hao
;
Yan, Bo
;
Li, Rong
;
Shao, Minhua
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitors (TKIs)
BIM deletion polymorphism
erlotinib
ABT-737
Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 卷号: 55, 期号: 46, 页码: 14248-14254
作者:
Song, Ting
;
Wang, Ziqian
;
Ji, Fangling
;
Feng, Yingang
;
Fan, Yudan
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2017/01/03
apoptosis
conformation analysis
drug design
inhibitors
structure elucidation
Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 卷号: 55, 期号: 46, 页码: 14248-14254
作者:
Song, Ting
;
Wang, Ziqian
;
Ji, Fangling
;
Feng, Yingang
;
Fan, Yudan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/12/12
apoptosis
conformation analysis
drug design
inhibitors
structure elucidation
长牡蛎内源性细胞凋亡通路及VDAC2基因功能的研究
学位论文
博士, 北京: 中国科学院大学, 2016
作者:
李颖翔
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  |  
浏览/下载:697/0
  |  
提交时间:2016/05/30
长牡蛎
细胞凋亡
线粒体
Bcl-2
VDAC2
Association between BIM deletion polymorphism and the risk of non-small cell lung cancer in Chinese
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 卷号: 9, 期号: 5
作者:
Xia, Jinjing
;
Xiong, Liwen
;
Chu, Tianqing
;
Ye, Junyi
;
Bai, Hao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/13
BIM
2903-bp deletion polymorphism
BH3 domain
Bcl-2 family
NSCLC
Integration and Oligomerization of Bax Protein in Lipid Bilayers Characterized by Single Molecule Fluorescence Study
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 卷号: 289, 期号: 46, 页码: 31708-31718
作者:
Luo, Lu
;
Yang, Jun
;
Liu, Dongxiang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Apoptosis
B-cell Lymphoma 2 (Bcl-2) Family
Bax
Lipid Bilayer
Single Molecule Biophysics
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