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浏览/检索结果: 共82条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy 期刊论文 Journal of Nanobiotechnology, 2021, 卷号: 19, 期号: 1 作者:  Shi,Junyu;  Zhang,Yi;  Zhang,Xiaomeng;  Chen,Ruiying;  Wei,Jianxu 收藏  |  浏览/下载：45/0  |  提交时间：2022/01/04 Resveratrol  Macrophage  Periodontitis  Liposome  Immune microenvironment  Local delivery   Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：24/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13 作者:  Zhang, Qing;  Chen, Lin-hai;  Yang, Hui;  Fang, You-chen;  Wang, Si-wei 收藏  |  浏览/下载：45/0  |  提交时间：2022/01/18 GPR84  medium chain fatty acid receptor  GPCR  inflammatory bowel diseases  ulcerative colitis  NLRP3 inflammasome  macrophages   Advancing COVID-19 diagnosis with privacy-preserving collaboration in artificial intelligence 期刊论文 NATURE MACHINE INTELLIGENCE, 2021, 卷号: 3, 期号: 12, 页码: 1081-1089 作者:  Bai, Xiangd;  Wang, Hanchen;  Ma, Liya;  Xu, Yongchao;  Gan, Jiefeng 收藏  |  浏览/下载：50/0  |  提交时间：2022/01/18 Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Dong, Ying;  Tang, Bi-xi;  Wang, Qi;  Zhou, Li-wei;  Li, Cong 收藏  |  浏览/下载：73/0  |  提交时间：2022/01/04 idiopathic pulmonary fibrosis  DDRs  kinase inhibitor  indazole derivatives  XBLJ-13  nintedanib  bleomycin-induced pulmonary fibrosismouse model   Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site 期刊论文 ACS CHEMICAL BIOLOGY, 2021, 卷号: 16, 期号: 11, 页码: 2444-2452 作者:  Wang, Jiang;  Yang, Dehua;  Cheng, Xi;  Yang, Linlin;  Wang, Zhaohui 收藏  |  浏览/下载：25/0  |  提交时间：2022/01/04 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11 作者:  Fan, Shijie;  Yue, Liyan;  Wan, Wei;  Zhang, Yuanyuan;  Zhang, Bidong 收藏  |  浏览/下载：80/0  |  提交时间：2021/12/16 covalent modification  probes  proteome  LC3  post-translational modification   Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation 期刊论文 JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251 作者:  Li, Heng;  Zhang, Xianglei;  Xiang, Caigui;  Feng, Chunlan;  Fan, Chen 收藏  |  浏览/下载：86/0  |  提交时间：2021/11/04 PDE4  Arctigenin  Psoriasis  Inflammation   Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11 作者:  Li, Bo;  Li, Heng;  Zhu, Zhengdan;  Xiang, Caigui;  Xu, Zhijian 收藏  |  浏览/下载：98/0  |  提交时间：2021/11/04 Anti-inflammatory activity  TNF alpha  ER beta  IBD Arylisoquinolones