Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

doi:10.1186/s12951-021-01175-x

	Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
	Shi,Junyu 2; Zhang,Yi 2,3; Zhang,Xiaomeng 2; Chen,Ruiying 2; Wei,Jianxu 2; Hou,Jiazhen 3; Wang,Bing 3; Lai,Hongchang 2; Huang,Yongzhuo 1,3,4,5
刊名	Journal of Nanobiotechnology
	2021-12-20
卷号	19 期号:1
关键词	Resveratrol Macrophage Periodontitis Liposome Immune microenvironment Local delivery
DOI	10.1186/s12951-021-01175-x
通讯作者	Lai,Hongchang(laihongchang@sjtu.edu.cn) ; Huang,Yongzhuo(yzhuang@simm.ac.cn)
英文摘要	AbstractBackgroundPeriodontitis is a complicated inflammatory disease that damages the tooth-supporting tissues, with limited pharmacotherapy?available. Macrophage-targeting therapy is promising for inflammatory diseases. Resveratrol (RSV), a nonflavonoid polyphenol, is known for its anti-inflammatory and immunomodulatory effects. However, its medical application is limited by its poor stability and water-solubility, as well as its low bioavailability.ResultA therapeutic resveratrol-loaded liposomal system (Lipo-RSV) was developed to treat periodontitis. The physical properties of Lipo-RSV and its ability to regulate macrophages were investigated. The results showed that Lipo-RSV had good biocompatibility and could re-educate the inflammatory macrophages from M1- to M2-like phenotype through activating p-STAT3 and downregulating p-STAT1. Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-κB signal and inflammasomes, thereby reducing the?pro-inflammatory cytokines IL-1β, IL-6, and TNF-α.ConclusionThese results revealed that Lipo-RSV could be a potential therapeutic system for the antibiotic-free treatment for periodontal diseases.Graphical Abstract
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12951-021-01175-X
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/298807]
专题	中国科学院上海药物研究所
通讯作者	Lai,Hongchang; Huang,Yongzhuo
作者单位	1.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients 2.Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineCollege of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Department of Implant Dentistry 3.Shanghai Institute of Materia Medica, Chinese Academy of Sciences; State Key Laboratory of Drug Research 4.Zhongshan Institute for Drug Discovery, SIMM, CAS 5.Taizhou University, School of Advanced Study, Institute of Natural Medicine and Health Product
推荐引用方式 GB/T 7714	Shi,Junyu,Zhang,Yi,Zhang,Xiaomeng,et al. Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy[J]. Journal of Nanobiotechnology,2021,19(1).
APA	Shi,Junyu.,Zhang,Yi.,Zhang,Xiaomeng.,Chen,Ruiying.,Wei,Jianxu.,...&Huang,Yongzhuo.(2021).Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy.Journal of Nanobiotechnology,19(1).
MLA	Shi,Junyu,et al."Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy".Journal of Nanobiotechnology 19.1(2021).