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Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:48/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
Decreased expression of mitochondrial aldehyde dehydrogenase‐2 induces liver injury via activation of the mitogen‐activated protein kinase pathway 期刊论文
Transplant International, 2016, 卷号: 29, 期号: 1, 页码: 98-107
作者:  Zhong, Zibiao;  Ye, Shaojun;  Xiong, Yan;  Wu, Lianxi;  Zhang, Meng
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/03
Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma 期刊论文
Cancer Letters, 2015, 卷号: 366, 期号: 1, 页码: 112-122
作者:  Zhang, Xin;  Yang, Xin-Rong;  Sun, Chao;  Hu, Bo;  Sun, Yun-Fan
收藏  |  浏览/下载:14/0  |  提交时间:2019/12/03
HCC  hepatocellular carcinoma  ATO  arsenic trioxide  APL  acute promyelocytic leukemia  PML  promyelocytic leukemia protein  RARα  retinoic acid receptor α  ALDH3A1  aldehyde dehydrogenase 3 family member A1  qRT-PCR  quantitative real-time reverse transcriptase polymerase chain reaction  TMA  tissue microarray  OS  overall survival  TTR  time to recurrence  DMEM  Dulbecco's modified Eagle's medium  CB7  1-[(4-fluorophenyl) sulfonyl]-2-methyl-1H-benzimidazole  siRNA  small interfering RNA  shRNA  small hairpin RNA  GFP  green fluorescent protein  MTT  3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide  ChIP  chromatin immunoprecipitation  ORF  open reading frame  ROS  reactive oxygen species  DCFH-DA  2,7-dichlorfluorescein-diacetate  AFP  α-fetoprotein  ALT  alanine aminotransferase  TTP  time to progression  GO  gene ontology  NFκB  nuclear factor kappa-light-chain-enhancer of activated B cells  Bcl-2  B-cell lymphoma 2  Promyelocytic leukemia protein  Aldehyde dehydrogenase 3 family member A1  Reactive oxygen species  Tumor growth  Drug resistance  
Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells. 期刊论文
OncoImmunology, 2015, 卷号: 4, 期号: 3, 页码: e990767
作者:  Lu, Lin;  Tao, Huimin;  Chang, Alfred E.;  Hu, Yangyang;  Shu, Guoshun
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes 期刊论文
Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, 卷号: 387, 期号: 1, 页码: 87-94
作者:  Fu, Si-Hai;  Zhang, Hong-Feng;  Yang, Zhong-Bao;  Li, Ting-Bo;  Liu, Bin
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/03
Mitochondrial aldehyde dehydrogenase, a potential drug target for protection of heart and brain from ischemia/reperfusion injury. 期刊论文
Current Drug Targets, 2014, 卷号: 15, 期号: 10, 页码: 948-955
作者:  Luo, Xiu-Ju;  Liu, Bin;  Ma, Qi-Lin;  Peng, Jun*
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/03
Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation 期刊论文
European Journal of Pharmacology, 2012, 卷号: 678, 期号: 1-3, 页码: 32-38
作者:  Lan He;  Bin Liu;  Zhong Dai;  Hong-Feng Zhang;  Yi-Shuai Zhang
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/03
Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer 期刊论文
European Journal of Cancer, 2012, 卷号: 48, 期号: 11, 页码: 1682-1691
作者:  Xu, Jing;  Mueller, Susan;  Nannapaneni, Sreenivas;  Pan, Lin;  Wang, Yuxiang
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/03
PITX3 gene polymorphism is associated with Parkinson's disease in Chinese population 期刊论文
Brain Research, 2011, 卷号: 1392, 页码: 116-120
作者:  Liu, Jia;  Sun, Qi-Ying;  Tang, Bei-Sha;  Hu, Liang;  Yu, Ren-He
收藏  |  浏览/下载:7/0  |  提交时间:2019/12/03
Identification of musashi-1 and ALDH1 as carcinogenesis, progression, and poor-prognosis related biomarkers for gallbladder adenocarcinoma 期刊论文
Cancer Biomarkers, 2010, 卷号: 8, 期号: 3, 页码: 113-121
作者:  Liu, Dong-Cai;  Yang, Zhu-Lin*;  Jiang, Song
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03


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