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上海药物研究所 [5]
厦门大学 [2]
大连理工大学 [2]
合肥物质科学研究院 [2]
金属研究所 [1]
大连化学物理研究所 [1]
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期刊论文 [19]
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2020 [2]
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Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:
Gao, Yang
;
Wen, Pengbo
;
Chen, Bin
;
Hu, Guanshuo
;
Wu, Lijun
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/11/30
CDC20
radiotherapy
Mcl-1
p-Chk1
mitochondrial-dependent apoptotic pathway
Combined cell death of co-exposure to aldehyde mixtures on human bronchial epithelial BEAS-2B cells: Molecular insights into the joint action
期刊论文
CHEMOSPHERE, 2020, 卷号: 244
作者:
Zhang, Sen
;
Zhang, Jingni
;
Cheng, Wanyan
;
Chen, Huan
;
Wang, An
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/11/26
Formaldehyde
Acrolein
Combined action
Cell death
Apoptotic signaling pathway
Expression and Solution NMR Study of Multi-site Phosphomimetic Mutant BCL-2 Protein
期刊论文
PROTEIN AND PEPTIDE LETTERS, 2019, 卷号: 26, 页码: 449-457
作者:
Song, Ting
;
Cao, Keke
;
Fan, Yu dan
;
Zhang, Zhichao
;
Guo, Zong W.
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/02
Phosphorylated BCL-2
purification
NMR spectroscopy
structural change
chemical shift
BH3 binding groove
Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway
期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 3, 页码: 16
作者:
Liu, Yingjuan
;
Geng, Lihua
;
Zhang, Jingjing
;
Wang, Jing
;
Zhang, Qi
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/08/21
oligo-porphyran
PI3K/Akt
apoptosis
Parkinson's disease
neurobehavior
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
The BH3-only protein BAD mediates TNF alpha cytotoxicity despite concurrent activation of IKK and NF-kappa B in septic shock
期刊论文
CELL RESEARCH, 2018, 卷号: 28, 期号: 7, 页码: 701-718
作者:
Yan, Jie
;
Yuan, Xiang
;
Lin, Anning
;
Zhang, Hao
;
Xiang, Jialing
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/04/28
Tumor-necrosis-factor
Apoptotic Cell-death
In-vivo
Kinase Activation
Jnk Activation
Agonist Bad
Sepsis
Phosphorylation
Survival
Inflammation
Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2016, 卷号: 14, 期号: 11, 页码: 856-864
作者:
Feng Li-Xing
;
Sun Peng
;
Mi Tian
;
Liu Miao
;
Liu Wang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Agglutinin
Arisaema heterophyllum Blume
Human non-small-cell lung cancer A549 cell line
Apoptosis
Autophagy
agglutininisolatedfromarisemaheterophyllumblumeinducesapoptosisandautophagyina549cellsthroughinhibitingpi3kaktpathwayandinducingerstress
期刊论文
chinesejournalofnaturalmedicines, 2016, 卷号: 014, 期号: 011, 页码: 856
作者:
Feng Lixing
;
Sun Peng
;
Mi Tian
;
Liu Miao
;
Liu Wang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
Agglutinin
Arisaema heterophyllum Blume
Human non-small-cell lung cancer A549 cell line
Apoptosis
Autophagy
A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1
期刊论文
PIGMENT CELL & MELANOMA RESEARCH, 2015, 卷号: 28, 页码: 161-170
作者:
Liu, Yubo
;
Xie, Mingzhou
;
Song, Ting
;
Sheng, Hongkun
;
Yu, Xiaoyan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/09
melanoma
Mcl-1 phosphorylation
BH3 mimetics
Bcl-2 family
mitogen-activated protein kinase pathway
Mechanism of the inhibition of the STAT3 signaling pathway by EGCG
期刊论文
ONCOLOGY REPORTS, 2013, 卷号: 30, 期号: 6, 页码: 2691-2696
作者:
Wang, Yang
;
Ren, Xuequn
;
Deng, Chaoyang
;
Yang, Lu
;
Yan, Erfu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
epigallocatechin-3-gallate
signal transducer and activator of transcription 3
hepatocellular carcinoma
molecular docking
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