ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  

CHEMOTHERAPEUTIC-AGENTS  HERBA-EPIMEDII  CANCER-CELLS  TRANSPORTERS  EXPRESSION  FLAVONOIDS  PROTEIN-1  ABCB1  PHARMACOKINETICS  PROLIFERATION  Osteosarcoma  Icaritin  Multidrug resistance  MDR1  MRP1  

ABCG2  Multidrug resistance  Marsdenia tenacissima  MRP1  P-glycoprotein  Polyoxypregnane compounds  

SNPs  single nucleotide polymorphisms  NFKB1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  PPP1R13L/IASPP/RAI  protein phosphatase 1, regulatory (inhibitor) subunit 13 like/inhibitory member of the ASPP family/RelA-associated inhibitor  CD3EAP/ASE-1  CD3e molecule, epsilon-associated protein/antisense to ERCC1  htSNPs  haplotype-tagging single nucleotide polymorphisms  LD  linkage disequilibrium  OR  Odd Ratio  95% CI  95% confidence interval  MDR  multifactor dimensionality reduction  NFKB1 and PPP1R13L and CD3EAP  Common variants  Interaction  Lung cancer  Chinese  

Gypenoside aglycon  Gynostemma pentaphyllum  Multidrug resistance (MDR)  KB/VCR cells  P-glycoprotein (P-gp)  Multidrug resistance associated protein 1 (MRP1)