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科研机构
北京大学 [5]
上海药物研究所 [4]
南开大学 [2]
昆明动物研究所 [2]
水生生物研究所 [1]
武汉病毒研究所 [1]
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期刊论文 [19]
学位论文 [1]
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2018 [3]
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2015 [3]
2014 [2]
2013 [4]
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Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
期刊论文
JOURNAL OF MOLECULAR BIOLOGY, 2018, 卷号: 430, 期号: 21
作者:
Peng, Ling
;
Wang, Longlong
;
Zhang, Yingpei
;
Dong, Aiwu
;
Shen, Wen-Hui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
ALFIN-like
DUF3594 domain
PRC1 complex
crystal structure
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
The formation and modification of chromatin-like structure of human parvovirus b19 regulate viral genome replication and rna processing
期刊论文
Virus research, 2017, 卷号: 232, 页码: 134-138
作者:
Xu, Huanzhou
;
Hao, Sujuan
;
Zhang, Junmei
;
Chen, Zhen
;
Wang, Hanzhong
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  |  
浏览/下载:85/0
  |  
提交时间:2019/05/08
B19v
Chromatin-like structure
Dac
Replication
Rna splicing
Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila
期刊论文
CELL CYCLE, 2016, 卷号: 15, 期号: 14, 页码: 1855-1864
作者:
Yan, Guan-Xiong
;
Dang, Huai
;
Tian, Miao
;
Zhang, Jing
;
Shodhan, Anura
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2016/11/21
anaphase initiation
cyclin
chromosome segregation
meiosis
Tetrahymena thermophila
Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of cenp-n
期刊论文
Genes & development, 2015, 卷号: 29, 期号: 10, 页码: 1058-1073
作者:
Fang, Junnan
;
Liu, Yuting
;
Wei, Yun
;
Deng, Wenqiang
;
Yu, Zhouliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/05/10
Rg loop
Cenp-a
Higher-order chromatin structure
Cenp-n
Chromosome congression
Cell cycle
CTCF在HSV-1转录复制中的作用和CTCF参与DNA损伤修复的研究
学位论文
博士, 北京: 中国科学院研究生院, 2015
作者:
郎丰超
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2016/06/29
I型人类疱疹病毒
宿主蛋白
CTCF
转录复制
DNA损伤修复
Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 3, 页码: 1281-1297
作者:
Zhao, Lele
;
Wang, Yingqing
;
Cao, Danyan
;
Chen, Tiantian
;
Wang, Qi
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  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Crystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.
期刊论文
Journal of Biological Chemistry, 2014, 卷号: Vol.289 No.40, 页码: 27376-27385
-
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/27
KEYWORDS: CUTL Domain
Chromatin Regulation
Coordination Mechanism
Crystal Structure
DNA Binding
DNA-binding Protein
Gene Regulation
Global Gene Regulation
SATB1
Scaffold Protein
Crystal Structure of the Ubiquitin-like Domain-CUT Repeat-like Tandem of Special AT-rich Sequence Binding Protein 1 (SATB1) Reveals a Coordinating DNA-binding Mechanism*
期刊论文
JBC, 2014, 卷号: Vol.289 No.40, 页码: 27376-27385
作者:
Zheng Wang
;
Xue Yang
;
Shuang Guo
;
Yin Yang
;
Xun-Cheng Su
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/27
Chromatin Regulation
Crystal Structure
DNA-binding Protein
Gene Regulation
Scaffold Protein
CUTL Domain
DNA Binding
SATB1
Coordination Mechanism
Global Gene Regulation
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