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科研机构
中南大学 [10]
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期刊论文 [10]
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2018 [1]
2014 [2]
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Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP)
期刊论文
Future oncology (London, England), 2014, 卷号: 10, 期号: 11, 页码: 1827-1841
作者:
Yang, Danwen
;
Kathawala, Rishil J.
;
Chufan, Eduardo E.
;
Patel, Atish
;
Ambudkar, Suresh V.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
ABC transporter
ABCB1
ABCG2
multidrug resistance
tivozanib
tyrosine kinase inhibitor
PTEN Regulates BCRP/ABCG2 and the Side Population through the PI3K/Akt Pathway in Chronic Myeloid Leukemia
期刊论文
PLOS ONE, 2014, 卷号: 9, 期号: 3, 页码: e88298
作者:
Huang, Fang-Fang
;
Zhang, Li
;
Wu, Deng-Shu
;
Yuan, Xiao-Yu
;
Chen, Fang-Ping
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Leukemia cells,Cancer treatment,Flow cytometry,Reverse transcriptase-polymerase chain reaction,Small interfering RNAs,Stem cell therapy,Leukemias,Synthesis phase
Survivin up-regulates the expression of breast cancer resistance protein (BCRP) through attenuating the suppression of p53 on NF-kappaB expression in MCF-7/5-FU cells.
期刊论文
The International Journal of Biochemistry & Cell Biology, 2013, 卷号: 45, 期号: 9, 页码: 2036-2044
作者:
Wang, Qing-ping
;
Wang, Yu
;
Wang, Xue-dong*
;
Mo, Xi-ming
;
Gu, Juan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
5-FU
5-fluorouracil
BCRP
Breast cancer resistance protein
MDR
MX
Multidrug resistance
NF-kappaB
Survivin
breast cancer resistance protein
mitoxantrone
multidrug resistance
p53
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
期刊论文
Biochemical Pharmacology, 2012, 卷号: 84, 期号: 6, 页码: 766-774
作者:
Ye-Hong Kuang
;
Jay P. Patel
;
Kamlesh Sodani
;
Chung-Pu Wu
;
Li-Qiu Liao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
OSI-930
{N-(4-trifluoromethoxyphenyl)3-((quinolin-4-ylmethyl) amino) thiophene-2-carboxamide}
ABC
ATP binding cassette
ABCG2 (BCRP/MXR/ABCP)
ABC subfamily G member 2
MDR
multidrug resistance
P-gp
P-glycoprotein
ABCCs (MRPs)
ABC subfamily C member
RTK
receptor tyrosine kinases
KDR
kinase insert domain receptor
TKIs
tyrosine kinase inhibitors
IAAP
[125I]-iodoarylazidoprazosin
FTC
fumitremorgin C
MTT
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
DMSO
dimethylsulfoxide
OSI-930
ABC transporters
ABCG2
Multidrug resistance
Transcriptional suppression of breast cancer resistance protein (BCRP) by wild‐type p53 through the NF‐κB pathway in MCF‐7 cells
期刊论文
FEBS Letters, 2010, 卷号: 584, 期号: 15, 页码: 3392-3397
作者:
Wang, Xuedong
;
Wu, Xingang
;
Wang, Chengkun
;
Zhang, Weijia
;
Ouyang, Yongmei
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
BCRP
Breast cancer resistance protein
MRP
multidrug resistance-associated protein
P-gp
P-glycoprotein
NF-κB
nuclear factor kappa-B
RNAi
RNA interference
wt-p53
wild-type p53
PBS
phosphate balanced solution
EMSA
electrophoretic mobility shift assay
Wild-type p53
Breast cancer resistance protein
Nuclear factor kappa-B
Multidrug resistance (MDR)
Electrophoretic mobility shift assay (EMSA)
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
期刊论文
Biochemical Pharmacology, 2010, 卷号: 79, 期号: 2, 页码: 154-161
作者:
Kuang, Ye-Hong
;
Shen, Tong
;
Chen, Xiang
;
Sodani, Kamlesh
;
Hopper-Borge, Elizabeth
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
TKI
tyrosine kinase inhibitor
EGFR
epidermal growth factor receptor
MDR
multidrug resistance
ABC
ATP-binding cassette
P-gp (ABCB1)
P-glycoprotein
ABCG2
also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein)
MRP7 (ABCC10)
multidrug resistance protein 7
HER
human epidermal receptor
Tyrosine kinase inhibitor
EGFR
Lapatinib
Erlotinib
ABC transporters
MRP7/ABCC10
Multidrug resistance
Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer
期刊论文
Cancer Chemotherapy and Pharmacology, 2009, 卷号: 63, 期号: 6, 页码: 1103-1110
作者:
Yuan, Jianhui
;
Lv, Hui
;
Peng, Bo
;
Wang, Chengkun
;
Yu, Yanhui
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
BCRP
5-Fluorouracil
Multidrug resistance
RNAi
Nilotinib (AMN107, Tasigna®) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters
期刊论文
Biochemical Pharmacology, 2009, 卷号: 78, 期号: 2, 页码: 153-161
作者:
Tiwari, Amit K.
;
Sodani, Kamlesh
;
Wang, Si-Rong
;
Kuang, Ye-Hong
;
Ashby, Charles R., Jr.
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
ABCB1 (P-gp)
P-glycoprotein
ABCG2
also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein)
ABCC1 (MRP1)
multidrug resistance protein 1
EGFR
epidermal growth factor receptor
HER
human epidermal receptor
TKI
tyrosine kinase inhibitor
PBS
phosphate-buffered saline
FTC
fumitremorgin C
E217βG
estradiol 17-β-d-glucuronide
d
MX
mitoxantrone
MTX
methotrexate
Nilotinib
ABC transporters
ABCB1
ABCG2
BCR-Abl
Tyrosine kinase inhibitor
Multidrug resistance
Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance
期刊论文
Biochemical Pharmacology, 2009, 卷号: 77, 期号: 6, 页码: 993-1001
作者:
Zhou, Ying
;
Hopper-Borge, Elizabeth
;
Shen, Tong
;
Huang, Xiao-Cong
;
Shi, Zhi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
MDR
multidrug resistance
ABC
ATP-binding cassette
BCRP/ABCG2/MXR
breast cancer resistance protein
P-gp/MDR1/ABCB1
P-glycoprotein
MRP7/ABCC10
multidrug resistance protein 7
cepharanthine
6′,12′-dimethoxy-2,2′-dimethyl-6,7-[methylenebis(oxy)oxyacan-than]
E217βG
17-β-estradiol-(17-beta-d-glucuronide)
d
VCR
vincristine
VBL
vinblastine
MTT
(3-(4,5-dimethylthiazol-2-yl)-3, 5-diphenylformazan
MRP7
MDR
Cepharanthine
Paclitaxel
E217βG transport
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