SGK  AKT  PI3K  Cancer  Signalling: Kinase  Inhibitor  

ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  

epithelial-mesenchymal transition  microRNA-29b  RIF  phosphatidylinositol 3-kinase  protein kinase B  signaling pathway  phosphatase and tensin homolog on chromosome 10  SF1670  

* AKT non-specific serine/threonine protein kinase  * CG control group  * NO nitric oxide  * NOS nitric oxide synthase  * PI3K phosphatidylinositol 3 kinase  * PLCG2 1-phosphatidylinositol 4  * RG restricted group  * RHOC Rho-related GTP-binding protein rhoc  * VDAC1 voltage-dependent anion-selective channel protein 1  * VEGF vascular endothelial growth factor  * iTRAQ isobaric tag for relative absolute quantitation  *5-bisphosphate phosphodiesterase gamma-2  *Capillary  *Feed intake restriction  *Placenta  *Pregnant goats  *Proteomics  

Akt  protein kinase B  Atg  autophagy related gene  CNS  central nervous system  COX-2  cyclooxygenase-2  CQ  chloroquine  ERK  extracellular signal-regulated kinase  IL-1β  interleukin-1β  iNOS  inducible nitric oxide synthase  JNK  c-jun NH2-terminal kinase  LPS  Lipopolysaccharide  MAPKs  mitogen-activated protein kinases  mTOR  mechanistic target of rapamycin  NO  nitric oxide  PI3K  phosphatidylinositol 3-kinase  PRR  pattern recognition receptor  TLR4  toll like receptor 4  TNF-α  tumor necrosis factor-α  20C  Autophagy  Mitogen-activated protein kinases (MAPKs)  Toll like receptor 4 (TLR4)  Protein kinase B (Akt)  Mechanistic target of rapamycin (mTOR)