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CORC

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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua
收藏  |  浏览/下载：32/0  |  提交时间：2021/08/17
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186
作者:  Zheng, Wei;  Wang, Zhen;  Jiang, Xiangrui;  Zhao, Qingjie;  Shen, Jingshan
收藏  |  浏览/下载：24/0  |  提交时间：2021/05/24
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China 期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 页码: 13
作者:  Chen, Chenyang;  Luo, Fei;  Wu, Panyun;  Huang, Yiyuan;  Das, Avash
收藏  |  浏览/下载：32/0  |  提交时间：2020/03/18
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
收藏  |  浏览/下载：134/0  |  提交时间：2019/06/28
Chrysin ameliorates ANTU-induced pulmonary edema and pulmonary arterial hypertension via modulation of VEGF and eNOs 期刊论文
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 卷号: 33, 期号: 7
作者:  Lei, Zhang;  Wang, Ye;  Wang, Linlin
收藏  |  浏览/下载：17/0  |  提交时间：2019/12/05
Silencing PDK1 limits hypoxia-induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2019, 卷号: 18, 期号: 1
作者:  Di, Ruomin;  Yang, Zhongzhou;  Xu, Peng;  Xu, Yingjia
收藏  |  浏览/下载：19/0  |  提交时间：2019/12/05
Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O-2 Sensitive Voltage-Gated K+ Channels 期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 9
作者:  Fan, Fenling;  Tian, Hua;  Geng, Jie;  Deng, Jizhao;  Liu, Ya
收藏  |  浏览/下载：23/0  |  提交时间：2019/11/19
Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy. 期刊论文
Naunyn-Schmiedeberg's archives of pharmacology, 2019
作者:  Feng Wei;  Wang Jian;  Yan Xin;  Zhai Cui;  Shi Wenhua
收藏  |  浏览/下载：39/0  |  提交时间：2019/11/19

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