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TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2 (vol 81, pg 1004, 2020)
期刊论文
DRUG DEVELOPMENT RESEARCH, 2021, 页码: 1
作者:
Niu, Gang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/12/01
coronavirus
cytokine storm
literature mining
renin
angiotensin system
topic inference
TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2
期刊论文
DRUG DEVELOPMENT RESEARCH, 2020, 卷号: 81, 期号: 8, 页码: 1004-1018
作者:
Ji, Xiaoyang
;
Tan, Wenting
;
Zhang, Chunming
;
Zhai, Yubo
;
Hsueh, Yiching
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/12/01
coronavirus
cytokine storm
literature mining
renin‐
angiotensin system
topic inference
Deficiency in the membrane protein Tmbim3a/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 30, 页码: 11445-11457
作者:
Chen, Kai
;
Li, Xixi
;
Song, Guili
;
Zhou, Tong
;
Long, Yong
收藏
  |  
浏览/下载:181/0
  |  
提交时间:2019/09/10
endoplasmic reticulum stress (ER stress)
calcium intracellular release
apoptosis
zebrafish
stress response
apoptosis
calcium homeostasis
cold exposure
endoplasmic reticulum stress
calcium homeostasis
Grinaa
transmembrane BAX inhibitor motif (TMBIM)
unfolded protein response (UPR)
cell death
Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury
期刊论文
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2019, 卷号: 471, 期号: 4
作者:
Cao, Yingxue
;
Guan, Yi
;
Xu, Yun-Yu
;
Hao, Chuan-Ming
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Prostacyclin
Ischemia-reperfusion injury
IP receptor
Renal blood flow
Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O-2 Sensitive Voltage-Gated K+ Channels
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 9
作者:
Fan, Fenling
;
Tian, Hua
;
Geng, Jie
;
Deng, Jizhao
;
Liu, Ya
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/11/19
Kv channel
EP4 receptor
O-2-sensitive Kv channel
prostanoids
IP receptor
pulmonary arterial hypertension
Beraprost
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation
期刊论文
2019, 卷号: 212, 页码: 36-53
作者:
Ai Q D
;
Chen Chen
;
Chu Shifeng
;
Zhang Zhao
;
Luo Yun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/01/03
ASC = apoptosis-associated speck-like protein containing a caspase activation recruitment domain
BCA = bicinchoninic acid
BSA = bovine serum albumin
CCA = common carotid artery
CCR4 = C-C chemokine receptor type 4
CKLF1 = chemokine-like factor 1
CO-IP = coimmunoprecipitation
ECA = external carotid artery
ELISA = enzyme-linked immunosorbent assay
FDA = Food and Drug Administration
I/R = ischemic/reperfusion
ICA = internal carotid artery
IL-18 = interleukin 18
IL-1β = interleukin 1β
LDH = lactate dehydrogenase
NLRP3 = NOD-like receptor protein 3
PBS = phosphate-buffered saline
SD = standard deviation
TNF-α = tumor necrosis factor α
TTC = 2
3
5-triphenyltetrazolium-chloride
WT = wild-type
pMCAO = permanent middle cerebral artery occlusion
pro-Caspase-1 = precursor Caspase-1
qPCR = quantitative real-time PCR
tMCAO = transient middle cerebral artery occlusion
tPA = tissue plasminogen activator
NK cells in cerebral ischemia
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 卷号: 109, 页码: 547-554
作者:
Chen, Chen
;
Ai, Qi-Di
;
Chu, Shi-Feng
;
Zhang, Zhao
;
Chen, Nai-Hong*
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/12/27
tPA
tissue plasminogen activator
IS
ischemic stroke
BBB
blood-brain barrier
IFN-γ
interferon-γ
pMCAO
permanent middle cerebral artery occlusion
tMCAO
transient middle cerebral artery occlusion
CX3CR1
CX3CL1 receptor
CNS
central nervous system
AchE
acetylcholine esterase
CFSE
arboxyfluorescein diacetate succinimidyl ester
HI
hypoxic ischemia
MCAO IP-10
interferon-inducible protein-10
IL
interleukin
GFAP
glial fibrillary acidic protein
tg
transgenic
WT
wild-type
APC
antigen presenting cell
SAI
stroke-associated infection
STAT3
signal transducer and activator of transcription-3
HPA
hypothalamic-pituitary-adrenal
cSVD
cerebral small vessel disease
SHR
spontaneously hypertensive rat
CSF
cerebrospinal fluid
aSAH
aneurysmal subarachnoid hemorrhage
DCI
delayed cerebral ischemia
MRI
magnetic resonance imaging
CT
computed tomography
EVs
extracellular vesicles
MSC
mesenchymal stem cell
MNCs
bone marrow-derived mononuclear cells
CpG-ODN
cytosine-guanine oligodideoxynucleotide
TLR9
toll-like receptor 9
TNF
tumor necrosis factor
NK cells
Cerebral ischemia
Inflammation
Immunodpression
Infection
Interfering RNA against PKC-alpha inhibits TNF-alpha-induced IP(3)R1 expression and improves glomerular filtration rate in rats with fulminant hepatic failure
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2018, 卷号: 314, 期号: 5
作者:
Wang, Dong-Lei
;
Dai, Wen-Ying
;
Wang, Wen
;
Wen, Ying
;
Zhou, Ying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
acute kidney failure
fulminant hepatic failure
protein kinase C-alpha
type 1 inositol 1,4,5-trisphosphate receptor
tumor necrosis factor-alpha
AKR1C3, as a novel target of DAB2IP signaling, maintains the protein stability of androgen receptor splicing variant in prostate cancer
期刊论文
INTERNATIONAL JOURNAL OF UROLOGY, 2018, 卷号: 25, 页码: 211-211
作者:
Wu, Kaijie
;
Wang, Bin
;
Hsieh, Jer-Tsong
;
He, Dalin
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/11/19
Alleviation of palmitic acid‐induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R‐controlled Ca release
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 卷号: Vol.233 No.8, 页码: 6148-6157
作者:
Xiao, WC
;
Zhang, J
;
Chen, SL
;
Shi, YJ
;
Xiao, F
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/26
augmenter
of
liver
regeneration
BCL‐2
endoplasmic
reticulum
stress
inositol‐1,4,5‐
trisphosphate
receptor
non‐alcoholic
steatohepatitis
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