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上海药物研究所 [29]
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Full-Length Transcriptome Analysis of Plasmodium falciparum by Single-Molecule Long-Read Sequencing
期刊论文
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 卷号: 11, 页码: 11
作者:
Yang, Mengquan
;
Shang, Xiaomin
;
Zhou, Yiqing
;
Wang, Changhong
;
Wei, Guiying
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/05/24
Plasmodium falciparum
small protein
long non-coding RNA
alternative splicing
full-length RNA-seq
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase
期刊论文
ACS INFECTIOUS DISEASES, 2020, 卷号: 6, 期号: 11, 页码: 2994-3003
作者:
Butler, Joshua H.
;
Baptista, Rodrigo P.
;
Valenciano, Ana L.
;
Zhou, Bin
;
Kissinger, Jessica C.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Plasmodium
PfPARE
structure-resistance relationship study
Malaria Box
Pathogen Box
lindenane sesquiterpenoid dimers
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:
Liang, Xiaofei
;
Jiang, Zongru
;
Huang, Zhenghui
;
Li, Feng
;
Chen, Cheng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/11/26
PI4K kinase
Kinase inhibitor
Malaria
Blood stage
Liver stage
Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques
期刊论文
SEPARATION AND PURIFICATION REVIEWS, 2019, 卷号: 48, 期号: 3, 页码: 242-266
作者:
Zhang, Lili
;
Jiang, Yanyan
;
Li, Ning
;
Pu, Yiqiong
;
Zhang, Tong
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Artemisinin derivatives
quantitative analysis
spectroscopy
chromatography
mass spectrometry
Biological Activities of Artemisinin Derivatives Beyond Malaria
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 3, 页码: 205-222
作者:
Liu, Xiaoyan
;
Cao, Jianguo
;
Huang, Guozheng
;
Zhao, Qingjie
;
Shen, Jingshan
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
Anticancer activity
Antiviral activity
Artemisinin
Artemisinin derivatives
Dimer
Trimer
Different erythrocyte microrna profiles in low- and high-altitude individuals
期刊论文
Frontiers in physiology, 2018, 卷号: 9, 页码: 9
作者:
Sun, Liping
;
Fan, Fengyan
;
Li, Ruilin
;
Niu, Beifang
;
Zhu, Liguo
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2019/05/09
High-altitude hypoxia
Tibet
Han chinese
Tibetan
Erythrocyte-derived micrornas
Projecting potential spatial and temporal changes in the distribution of Plasmodium vivax and Plasmodium falciparum malaria in China with climate change
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2018, 卷号: 627, 页码: 1285-1293
作者:
Hundessa, Samuel
;
Williams, Gail
;
Li, Shanshan
;
Liu, De Li
;
Cao, Wei
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/05/23
P. vivax
P. falciparum
Climate
Malaria
RCP
Scenario
Stabilization of a chimeric malaria antigen in separation and purification through efficient inhibition of protease activity by imidazole
期刊论文
PROCESS BIOCHEMISTRY, 2018, 卷号: 65, 页码: 213-219
作者:
Guo, Fangxia
;
Liu, Yongdong
;
Zhang, Chun
;
Wang, Qi
;
Gao, Yuhui
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2018/06/11
Multi-epitope
Malaria Antigen
Purification
Degradation
Imidazole
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