Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques

doi:10.1080/15422119.2018.1560331

	Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques
	Zhang, Lili 1; Jiang, Yanyan 3; Li, Ning 4; Pu, Yiqiong 2; Zhang, Tong 1,2; Wang, Bing 1,5
刊名	SEPARATION AND PURIFICATION REVIEWS
	2019-07-03
卷号	48 期号:3 页码:242-266
关键词	Artemisinin derivatives quantitative analysis spectroscopy chromatography mass spectrometry
ISSN号	1542-2119
DOI	10.1080/15422119.2018.1560331
通讯作者	Zhang, Tong(zhangtdmj@hotmail.com) ; Wang, Bing(bwang@simm.ac.cn)
英文摘要	Research on artemisinin and its derivatives (ARTDs) were initiated due to their outstanding anti-malarial effects. In the past few decades, considerable efforts have been made to extend the clinical applications of ARTDs. However, some ARTDs have a low aqueous solubility, short half-life in vivo and instability due to an endoperoxide bridge in their structures that also contributes to a poor bioavailability. The development of efficient quantitative analysis methods is needed for many branches of research, such as the chemical compound determination in plants, drug quality control and drug metabolism studies. The analysis methods used to detect ARTDs include spectroscopy, liquid chromatography, mass spectrometry and immunoassays. However, a systematic quantitative analysis of these compounds as the very first step in many studies has not been always conducted. Thus, this review presents a comprehensive overview of available analytical methods for in vivo and in vitro quantitation of ARTDs. It generalizes and compares the various methods focusing on sample preparation.
资助项目	Program of Shanghai Committee of Science and Technology[17401902300] ; Program of Shanghai Academic/Technology Research Leader[18XD1403700] ; National Scientific and Technological Major Special Project of China[2018ZX09201008-002] ; Innovation/Entrepreneurship Project of Shanghai University of Traditional Chinese Medicine[Y201857]
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY METHOD ; PLASMODIUM-FALCIPARUM MALARIA ; DRUG-DELIVERY-SYSTEM ; LC-MS/MS METHOD ; ASSEMBLED BIOTRANSESTERIFIED CYCLODEXTRINS ; NANOSTRUCTURED LIPID CARRIERS ; NEW-GUINEAN CHILDREN ; IN-VITRO ; METABOLITE DIHYDROARTEMISININ
WOS研究方向	Chemistry ; Engineering
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000472543800003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289486]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Tong; Wang, Bing
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Pharmaceut, Key Lab Smart Drug Delivery,Minist Educ & PLA, Shanghai, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lili,Jiang, Yanyan,Li, Ning,et al. Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques[J]. SEPARATION AND PURIFICATION REVIEWS,2019,48(3):242-266.
APA	Zhang, Lili,Jiang, Yanyan,Li, Ning,Pu, Yiqiong,Zhang, Tong,&Wang, Bing.(2019).Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques.SEPARATION AND PURIFICATION REVIEWS,48(3),242-266.
MLA	Zhang, Lili,et al."Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques".SEPARATION AND PURIFICATION REVIEWS 48.3(2019):242-266.