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CORC

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：23/0  |  提交时间：2022/01/04
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities 期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 8
作者:  Li, Ping;  Liu, Xiongxiong;  Zhao, Ting;  Li, Feifei;  Wang, Qiqi
收藏  |  浏览/下载：17/0  |  提交时间：2021/12/09
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:  Jiang, Kai-long;  Tong, Le-xian;  Wang, Tao;  Wang, Han-lin;  Hu, Xiao-bei
收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao
收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest 期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: 16, 页码: 9109-9123
作者:  Sun, Xiaohui;  Wang, Yan;  Ji, Kaihua;  Liu, Yang;  Kong, Yangyang
收藏  |  浏览/下载：22/0  |  提交时间：2021/12/15
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:  Gao, Yang;  Wen, Pengbo;  Chen, Bin;  Hu, Guanshuo;  Wu, Lijun
收藏  |  浏览/下载：49/0  |  提交时间：2020/11/30
Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin 期刊论文
RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2020, 页码: 10
作者:  Liu, Bingtao;  Chen, Weiqiang;  Li, Hongbin;  Li, Feifei;  Jin, Xiaodong
收藏  |  浏览/下载：22/0  |  提交时间：2021/12/15
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment 期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:  Zhang, Jinhua;  Si, Jing;  Gan, Lu;  Zhou, Rong;  Guo, Menghuan
收藏  |  浏览/下载：25/0  |  提交时间：2022/01/12
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan
收藏  |  浏览/下载：76/0  |  提交时间：2019/03/18

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