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科研机构
上海药物研究所 [240]
内容类型
期刊论文 [236]
会议论文 [4]
发表日期
2021 [14]
2020 [24]
2019 [11]
2018 [28]
2017 [24]
2016 [7]
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Progression and Regression of Abdominal Aortic Aneurysms in Mice
期刊论文
CURRENT MEDICAL SCIENCE, 2021, 页码: 8
作者:
Ding, Yu-chao
;
Zhang, Xian-jing
;
Zhang, Ji-xiu
;
Zhai, Zi-yi
;
Zhang, Mei-xia
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/12/01
abdominal aortic aneurysm
disease progression
disease regression
elastogenesis
lysyl oxidase
Development of Potent NEDD8-Activating Enzyme Inhibitors Bearing a Pyrimidotriazole Scaffold
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 9, 页码: 6161-6178
作者:
Xiong, Chaodong
;
Zhou, Lina
;
Tan, Jing
;
Song, Shanshan
;
Bao, Xubin
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:127/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia
期刊论文
Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1
作者:
Xiao,Shifu
;
Chan,Piu
;
Wang,Tao
;
Hong,Zhen
;
Wang,Shuzhen
收藏
  |  
浏览/下载:145/0
  |  
提交时间:2021/05/24
Sodium oligomannate
Efficacy
Safety
Alzheimer’s disease
Clinical trial
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