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上海药物研究所 [6]
烟台海岸带研究所 [2]
兰州理工大学 [1]
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期刊论文 [12]
会议论文 [1]
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2021 [13]
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Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11
作者:
Fan, Shijie
;
Yue, Liyan
;
Wan, Wei
;
Zhang, Yuanyuan
;
Zhang, Bidong
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/12/16
covalent modification
probes
proteome
LC3
post-translational modification
Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:
Jin, Tingting
;
Xu, Lei
;
Wang, Peipei
;
Hu, Xiaobei
;
Zhang, Runyuan
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  |  
浏览/下载:22/0
  |  
提交时间:2022/01/04
Exploring biological basis of Syndrome differentiation in coronary heart disease patients with two distinct Syndromes by integrated multi-omics and network pharmacology strategy
期刊论文
Chinese Medicine, 2021, 卷号: 16, 期号: 1
作者:
Wu,Gaosong
;
Zhao,Jing
;
Zhao,Jing
;
Song,Nixue
;
Zheng,Ningning
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  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
Coronary heart disease
Syndrome differentiation
Traditional Chinese Medicine
Proteomics
Metabolomics
Network pharmacology
Rapid greening response of China's 2020 spring vegetation to COVID-19 restrictions: Implications for climate change
期刊论文
SCIENCE ADVANCES, 2021, 卷号: 7, 期号: 35, 页码: 7
作者:
Su, Fenzhen
;
Fu, Dongjie
;
Yan, Fengqin
;
Xiao, Han
;
Pan, Tingting
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  |  
浏览/下载:62/0
  |  
提交时间:2021/11/05
Ca Saturation Determines Crop Growth in Acidic Ultisols Derived from Different Parent Materials
期刊论文
EURASIAN SOIL SCIENCE, 2021, 卷号: 54, 期号: 8, 页码: 1215-1227
作者:
Zhou, Shiwei
;
Liang, Wenjun
;
Zeng, Tingting
;
Liu, Xiao
;
Meng, Ling
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  |  
浏览/下载:70/0
  |  
提交时间:2021/10/21
exchangeable Ca
Al ratio
Chinese cabbage
wheat
pot experiments
soil acidity
Impact of diurnal temperature range on hospital admissions for cardiovascular disease in Jiuquan, China
期刊论文
URBAN CLIMATE, 2021, 卷号: 38
作者:
Zhai, Guangyu
;
Zhang, Kuan
;
Zhou, Wenjuan
;
Wu, Tingting
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  |  
浏览/下载:19/0
  |  
提交时间:2021/10/14
Diurnal temperature range
Cardiovascular disease
Hospital admission
Impact
Distributed lag non-linear model
Nitrogen availability improves the physiological resilience of coral endosymbiont Cladocopium goreaui to high temperature
期刊论文
JOURNAL OF PHYCOLOGY, 2021, 页码: 12
作者:
Zhou, Zhi
;
Zhang, Kaidian
;
Wang, Lingui
;
Su, Yilu
;
Wang, Jierui
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  |  
浏览/下载:62/0
  |  
提交时间:2021/06/07
apoptosis
heat stress
nitrogen limitation
stress response
symbiodiniaceae
Comparative validation of multi-instance instrument segmentation in endoscopy: Results of the ROBUST-MIS 2019 challenge
期刊论文
MEDICAL IMAGE ANALYSIS, 2021, 卷号: 70, 页码: 26
作者:
Ross, Tobias
;
Reinke, Annika
;
Full, Peter M.
;
Wagner, Martin
;
Kenngott, Hannes
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  |  
浏览/下载:46/0
  |  
提交时间:2021/06/07
Multi-instance instrument
Minimally invasive surgery
Robustness and generalization
Surgical data science
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12
作者:
Lin, Tingting
;
Li, Jiacheng
;
Liu, Liping
;
Li, Yuanqing
;
Jiang, Hualiang
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2021/05/24
CDK2 inhibitor
Selectivity
Anti-proliferative potency
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia
期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:
Jin, Tingting
;
Wang, Peipei
;
Long, Xiubing
;
Jiang, Kailong
;
Song, Pinrao
收藏
  |  
浏览/下载:133/0
  |  
提交时间:2021/05/24
CHK1 inhibitor
diaminopyrimidine
DNA damage response
oral bioavailability
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