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浏览/检索结果: 共40条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：22/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Dong, Ying;  Tang, Bi-xi;  Wang, Qi;  Zhou, Li-wei;  Li, Cong 收藏  |  浏览/下载：72/0  |  提交时间：2022/01/04 idiopathic pulmonary fibrosis  DDRs  kinase inhibitor  indazole derivatives  XBLJ-13  nintedanib  bleomycin-induced pulmonary fibrosismouse model   I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines 期刊论文 GREEN CHEMISTRY, 2021, 卷号: 23, 期号: 22, 页码: 9165-9171 作者:  Wei, Xiaohui;  Liang, Xuewu;  Li, Yazhou;  Liu, Qi;  Liu, Xuyi 收藏  |  浏览/下载：19/0  |  提交时间：2021/12/16 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11 作者:  Fan, Shijie;  Yue, Liyan;  Wan, Wei;  Zhang, Yuanyuan;  Zhang, Bidong 收藏  |  浏览/下载：77/0  |  提交时间：2021/12/16 covalent modification  probes  proteome  LC3  post-translational modification   Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation 期刊论文 JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251 作者:  Li, Heng;  Zhang, Xianglei;  Xiang, Caigui;  Feng, Chunlan;  Fan, Chen 收藏  |  浏览/下载：86/0  |  提交时间：2021/11/04 PDE4  Arctigenin  Psoriasis  Inflammation   5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19 作者:  Wang, Shuni;  Yang, Hong;  Su, Mingbo;  Lian, Fulin;  Cong, Zhanqing 收藏  |  浏览/下载：79/0  |  提交时间：2021/11/04 NSD2  Methyltransferase  HTS  Multiple myeloma  5-Aminonaphthalene derivatives  Inhibitor   Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847 作者:  Wei, Dan;  Wang, Hanlin;  Zeng, Qinghe;  Wang, Wenjing;  Hao, Bingbing 收藏  |  浏览/下载：29/0  |  提交时间：2021/12/16 Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663 作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong 收藏  |  浏览/下载：15/0  |  提交时间：2021/12/16 Constitutive signal bias mediated by the human GHRHR splice variant 1 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Fulai;  Zhang, Chao;  Zou, Xinyu;  Zhang, Huibing 收藏  |  浏览/下载：24/0  |  提交时间：2021/12/01 class B1 GPCR  receptor bias  cancer  cell proliferation