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科研机构
上海药物研究所 [30]
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期刊论文 [24]
会议论文 [6]
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2021 [3]
2020 [3]
2018 [3]
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A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Jiang, Kai-long
;
Tong, Le-xian
;
Wang, Tao
;
Wang, Han-lin
;
Hu, Xiao-bei
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/05/24
CHK1 inhibitors
PY34
drug sensitivity
c-Myc
hematologic malignancies
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:
Wu, Qian
;
Chen, Dan-Qi
;
Sun, Lin
;
Huan, Xia-Juan
;
Bao, Xu-Bin
收藏
  |  
浏览/下载:113/0
  |  
提交时间:2021/05/24
N2817
Bivalent BET inhibitors
Monovalent BET inhibitors
TAF1
Anticancer activity
Structural basis of GPBAR activation and bile acid recognition
期刊论文
NATURE, 2020, 页码: 29
作者:
Yang, Fan
;
Mao, Chunyou
;
Guo, Lulu
;
Lin, Jingyu
;
Ming, Qianqian
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
Quantification of microbiota-related phenols and aromatic acids in mouse feces of a diabetic nephropathy model by simultaneous BDAPE derivatization using ultra-performance liquid chromatography-tandem mass spectrometry
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 卷号: 412, 期号: 13, 页码: 3241-3252
作者:
Zheng, Xiaoli
;
Duan, Haonan
;
Lin, Feifei
;
Li, Xiaomei
;
Shen, Jianhua
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Phenols
Aromatic acid
Microbiota
Uremic toxin
Simultaneous derivatization
2-Bromo-1-[4-(dimethylamino)phenyl] ethyl ketone
Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network -molecular docking-LC-MSE analysis
期刊论文
JOURNAL OF INTEGRATIVE MEDICINE-JIM, 2020, 卷号: 18, 期号: 3, 页码: 229-241
作者:
Zhang, Zi-jia
;
Wu, Wen-yong
;
Hou, Jin-jun
;
Zhang, Lin-lin
;
Li, Fei-fei
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Lung-toxin Dispelling Formula No. 1
COVID-19
3C-like protease
Network pharmacology
Molecular docking
Meridian tropism
Spongian diterpenes from Chinese marine sponge Spongia officinalis
期刊论文
FITOTERAPIA, 2018, 卷号: 127, 页码: 159-165
作者:
Han, Guan-Ying
;
Sun, Dong-Yu
;
Liang, Lin-Fu
;
Yao, Li-Gong
;
Chen, Kai-Xian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Spongia officinalis
Diterpene
3-Nor-spongian
Absolute configuration
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity
期刊论文
CELL DEATH & DISEASE, 2018, 卷号: 9
作者:
Leung, Elaine Lai Han
;
Luo, Lian Xiang
;
Liu, Zhong Qiu
;
Wong, Vincent Kam Wai
;
Lu, Lin Lin
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan
期刊论文
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2017, 卷号: 22, 期号: 1, 页码: 69-76
作者:
Huang, Ying
;
Zhang, Qi
;
Wang, Jian-Rong
;
Lin, Kai-Lei
;
Mei, Xuefeng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Amino acid
co-amorphous
intrinsic dissolution rate
small molecular excipients
solubility
valsartan
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