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科研机构
上海药物研究所 [42]
内容类型
期刊论文 [37]
会议论文 [5]
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2020 [3]
2019 [1]
2018 [3]
2017 [3]
2016 [3]
2015 [1]
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Chemistry [1]
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Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat, mouse, dog, pig, monkey and human liver microsomes
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 页码: 7
作者:
Li, Hao-Jv
;
Wei, Wen-Long
;
Li, Zhen-Wei
;
Yao, Chang-Liang
;
Wang, Meng-Yuan
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/12/24
Uncaria rhynchophylla
Indole alkaloids
Mass defect filter
Time-staggered targeted ion lists
Metabolite identification
Liver microsomes
Original Pharmacodynamic and pharmacokinetic effects of S086, a novel angiotensin receptor neprilysin inhibitor
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2020, 卷号: 129, 页码: 10
作者:
Sun, Jingchao
;
Xu, Wenjie
;
Hua, Huaijie
;
Xiao, Ying
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/12/24
Angiotensin receptor-NEP inhibitor
Heart failure
Neprilysin inhibitor
Angiotensin receptor blocker
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Enantioselective determination of ketamine in dog plasma by chiral liquid chromatography-tandem mass spectrometry
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2019, 卷号: 33, 期号: 9, 页码: 8
作者:
Li, Ranran
;
Zhong, Kan
;
Jiang, Jinfang
;
Zhan, Yuan
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
chiral stationary phases
enantioselective LC-MS
MS
ketamine
stereoselective pharmacokinetics
Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 6, 页码: 1048-1063
作者:
Zhong, Chen-chun
;
Chen, Feng
;
Yang, Jun-ling
;
Jia, Wei-wei
;
Li, Li
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
anlotinib
tyrosine kinase inhibitor
absorption
distribution
metabolism
excretion
pharmacokinetics
Testosterone-induced benign prostatic hyperplasia rat and dog as facile models to assess drugs targeting lower urinary tract symptoms
期刊论文
PLOS ONE, 2018, 卷号: 13, 期号: 1
作者:
Li, Jing
;
Tian, Yanxin
;
Guo, Shimeng
;
Gu, Haifeng
;
Yuan, Qianting
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
pharmacokineticsanddispositionofanlotinibanoraltyrosinekinaseinhibitorinexperimentalanimalspecies
期刊论文
actapharmacologicasinica, 2018, 卷号: 039, 期号: 006, 页码: 1048
作者:
Zhong Chenchun
;
Chen Feng
;
Yang Junling
;
Jia Weiwei
;
Li Li
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
酷氨酸
布置
动物种类
试验性
血浆蛋白质
相互作用
新陈代谢
CYP3A
A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2017, 卷号: 409, 期号: 28, 页码: 6559-6565
作者:
Su, Chong
;
Sun, Hui
;
Yang, Hong
;
Yin, Lei
;
Zhang, Jiwen
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
Ion exchange solid phase extraction
LC-MS/MS
Porcine relaxin
Ultrahigh performance liquid chromatography
Detecting drug-induced changes in ECG parameters using jacketed telemetry: Effect of different data reduction techniques
期刊论文
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2017, 卷号: 85, 页码: 38-48
作者:
Skinner, Matthew
;
Xing, Guozhen
;
Lu, Jing
;
Ren, Jin
;
Oldman, Karen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Data reduction
Electrocardiogram
Heart rate
Methods
Moxifloxacin
Non-human primate
Non-invasive telemetry
QT interval
Safety pharmacology
Super-interval
Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites
期刊论文
XENOBIOTICA, 2017, 卷号: 47, 期号: 3, 页码: 267-275
作者:
Zhou, Xin
;
Zhang, Fangrong
;
Chen, Chang
;
Guo, Zitao
;
Liu, Jia
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Curcumin
drug-drug interaction
OAT
OATP
rosuvastatin
transporter
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