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科研机构
上海药物研究所 [6]
合肥物质科学研究院 [3]
中国医学科学院 北京... [2]
上海生物化学与细胞生... [1]
内容类型
期刊论文 [12]
发表日期
2022 [3]
2021 [4]
2019 [2]
2018 [2]
2017 [1]
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The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study
期刊论文
CANCER MEDICINE, 2022
作者:
Yu, Xiaoqing
;
Si, Jinfei
;
Wei, Jingwen
;
Wang, Yanling
;
Sun, Yan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/12/23
EGFR-TKIs
non-small cell lung cancer (NSCLC)
real-world study
survival outcome
A Phase 2 Study of Befotertinib in Patients with EGFR T790M Mutated NSCLC after Prior EGFR TKIs
期刊论文
JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17
作者:
Lu, S.
;
Zhang, Y.
;
Zhang, G.
;
Zhou, J.
;
Cang, S.
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
third-generation EGFR-TKI
befotertinib
T790M
HER2 exon 20 insertion mutations in lung adenocarcinoma with leptomeningeal metastasis: a case report and response to poziotinib
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2022, 卷号: 11
作者:
Fan, Ying
;
Qin, Jing
;
Han, Na
;
Lu, Hongyang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/23
Leptomeningeal metastasis (LM)
cerebrospinal fluid
HER2 exon 20 insertion mutations
poziotinib
case report
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells
期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:
Zhang, Mi
;
Quan, Haitian
;
Fu, Li
;
Li, Yun
;
Fu, Haoyu
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
EGFR‐
mutant non‐
small cell lung cancer
famitinib
HS‐
10296
multi‐
targeted tyrosine kinase inhibitor
third‐
generation EGFR inhibitor
Biomimetic codelivery overcomes osimertinib-resistant NSCLC and brain metastasis via macrophage-mediated innate immunity
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2021, 卷号: 329, 页码: 1249-1261
作者:
Zhao, Pengfei
;
Zhang, Jiaxin
;
Wu, Aihua
;
Zhang, Meng
;
Zhao, Yuge
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2021/05/24
Brain targeting delivery
Tumor-associated macrophage
Osimertinib resistance
Brain metastasis
Innate immunity
Combination therapy
Discovery of a novel third generation EGFR TKI and identification of its potential mechanism of resistance
期刊论文
CANCER RESEARCH, 2019, 卷号: 79, 期号: 13, 页码: 2
作者:
Zhang, Tao
;
Qu, Rong
;
Chen, Chengbin
;
Tong, Linjiang
;
Feng, Fang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834
作者:
Niu, Ao
;
Wang, Yang
;
Yang, Yushe
;
Wei, Jianhai
;
Ding, Jian
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
irreversible inhibitors
EGFR(T79014)( )mutant
anti-tumor
xenograft model
cell proliferation
Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib
期刊论文
CLINICAL CANCER RESEARCH, 2018, 卷号: 24, 期号: 11, 页码: 2594-2604
作者:
Liu, Shengwu
;
Hai, Josephine
;
Wang, Xiaoen
;
Quinn, Max M.
;
Gao, Peng
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2019/04/28
Receptor Tyrosine Kinase
Phase-ii Trial
Bromodomain Inhibition
Combination Therapy
Acquired-resistance
Domain Mutations
Bet Bromodomains
Breast-cancer
Egfr
Mutant
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