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上海药物研究所 [2]
山东大学 [2]
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期刊论文 [10]
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Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:
Zhou, Yan
;
Du, Dao-Hai
;
Wang, Jia
;
Cai, Xiao-Qing
;
Deng, Alicia X.
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2020/07/01
embryonic ectoderm development
Enhancer of zeste homolog 2
fluorescence polarization
high-throughput screening
homogenous time-resolved fluorescence
inhibitor
polycomb repressive complex 2
EZH2 inhibition suppresses bladder cancer cell growth and metastasis via the JAK2/STAT3 signaling pathway
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 1
作者:
Chen, Zhiyuan
;
Du, Yang
;
Liu, Xiuheng
;
Chen, Hui
;
Weng, Xiaodong
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/05
bladder cancer
enhancer of zeste 2 polycomb repressive complex 2 subunit
janus kinase 2
signal transducer and activator of transcription 3
Enhancer of zeste 2 polycomb repressive complex 2 subunit promotes sorafenib resistance of hepatocellular carcinoma though insulin-like growth factor 1 receptor
期刊论文
ANTI-CANCER DRUGS, 2019, 卷号: 30, 期号: 7, 页码: 677-684
作者:
Hu, Jing
;
Zhang, Jing
;
Sun, Feifei
;
Qi, Mei
;
Su, Peng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
enhancer of zeste 2 polycomb repressive complex 2 subunit
hepatocellular carcinoma
insulin like growth factor 1 receptor
microRNAs
sorafenib resistant
GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation-induced photoaging of human skin fibroblast cells
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 卷号: 15, 期号: 4
作者:
Zhang, Guang
;
Qin, Haiyan
;
Zhang, Lianbo
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/12/05
photoaging
polycomb group genes
ultraviolet A
human skin fibroblast
enhancer of zeste 2 polycomb repressive complex 2 subunit
EZH2 inhibition promotes methyl jasmonate-induced apoptosis of human colorectal cancer through the Wnt/beta-catenin pathway
期刊论文
ONCOLOGY LETTERS, 2018, 卷号: 16, 期号: 1
作者:
Wang, Yao
;
Fan, Li
;
Cui, Chunguo
;
Wang, Yongkun
;
Liang, Tingting
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
methyl jasmonate
human colorectal cancer
enhancer of zeste 2 polycomb repressive complex 2 subunit
Wnt/beta-catenin
A missense variant in EZH2 is associated with colorectal cancer risk in a Chinese population
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 55, 页码: 94738-94742
作者:
Li, Huihui
;
Chang, Chunxiao
;
Shang, Yuhong
;
Qiang, Ling
;
Zhang, Baoxuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
colorectal cancer
susceptibility
enhancer of zeste 2 polycomb
repressive complex 2 subunit
exon region
missense variant
Identification of novel ezh2 inhibitors through pharmacophore-based virtual screening and biological assays
期刊论文
Bioorganic & medicinal chemistry letters, 2016, 卷号: 26, 期号: 15, 页码: 3813-3817
作者:
Wu, Yunlong
;
Hu, Junchi
;
Ding, Hong
;
Chen, Limin
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/05/09
Ezh2
Epigenetics
Prc2
Computational drug design
Pharmacophore-based virtual screening
Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 15, 页码: 3813-3817
作者:
Wu, Yunlong
;
Hu, Junchi
;
Ding, Hong
;
Chen, Limin
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
EZH2
Epigenetics
PRC2
Computational drug design
Pharmacophore-based virtual screening
EZH2 is overexpressed in laryngeal squamous cell carcinoma and enhances the stem-like properties of AMC-HN-8 cells
期刊论文
ONCOLOGY LETTERS, 2016, 卷号: 12, 期号: 2
作者:
Huang, Jiameng
;
Zhou, Liang
;
Chen, Hui
;
Wu, Chunping
;
Duo, Zhang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/06
enhancer of zeste 2 polycomb repressive complex 2 subunit
laryngeal squamous cell carcinoma
expression
stem-like properties
AMC-HN-8 cell line
Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway
期刊论文
AUTOPHAGY, 2015
Wei, Fu-Zheng
;
Cao, Ziyang
;
Wang, Xi
;
Wang, Hui
;
Cai, Mu-Yan
;
Li, Tingting
;
Hattori, Naoko
;
Wang, Donglai
;
Du, Yipeng
;
Song, Boyan
;
Cao, Lin-Lin
;
Shen, Changchun
;
Wang, Lina
;
Wang, Haiying
;
Yang, Yang
;
Xie, Dan
;
Wang, Fan
;
Ushijima, Toshikazu
;
Zhao, Ying
;
Zhu, Wei-Guo
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
autophagy
EZH2
histone modification
MTA2
MTOR pathway
EMBRYONIC STEM-CELLS
CHROMATIN-REMODELING COMPLEX
HISTONE DEACETYLASE
DNA-DAMAGE
MI-2/NURD COMPLEX
TUMOR-SUPPRESSOR
FACTOR CHD4
IN-VIVO
NURD
METHYLATION
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