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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia
收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers 期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:  Tao, Zhonghua;  Liu, Jianxia;  Li, Ting;  Xu, Hong;  Chen, Kai
收藏  |  浏览/下载:32/0  |  提交时间:2022/01/10
Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents 期刊论文
TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 40
作者:  Bai, Wenjing;  Ji, Jianxin;  Huang, Qiang;  Wei, Wei
收藏  |  浏览/下载:9/0  |  提交时间:2020/11/25
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas 期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:  Zhang, Qing;  Liu, Jian-He;  Liu, Jing-Li;  Qi, Chun-Ting;  Yan, Lei
收藏  |  浏览/下载:58/0  |  提交时间:2020/07/01
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer 期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 15
作者:  Jin, Nan;  Bi, Aiwei;  Lan, Xiaojing;  Xu, Jun;  Wang, Xiaomin
收藏  |  浏览/下载:60/0  |  提交时间:2020/07/01
Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs. 期刊论文
European journal of medicinal chemistry, 2019, 卷号: 164, 页码: 440-447
作者:  Shan Yuanyuan;  Si Ru;  Wang Jin;  Zhang Qingqing;  Zhou Huaxin
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/19
Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol. 期刊论文
European journal of medicinal chemistry, 2019, 卷号: 163, 页码: 1-9
作者:  Pan Xiaoyan;  Liang Liyuan;  Si Ru;  Wang Jin;  Zhang Qingqing
收藏  |  浏览/下载:23/0  |  提交时间:2019/11/19
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 5003-5015
作者:  Song, Qiaoling;  Sun, Xiaoxiao;  Guo, Hui;  Yu, Qiang
收藏  |  浏览/下载:19/0  |  提交时间:2019/01/08
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance 期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 135, 页码: 34-48
作者:  Zha, Gao-Feng;  Qin, Hua-Li*;  Youssif, Bahaa G. M.;  Amjad, Muhammad Wahab;  Raja, Maria Abdul Ghafoor
收藏  |  浏览/下载:14/0  |  提交时间:2019/12/04
Epidermal growth factor receptor (EGFR)  BRAF  Focal adhesion kinase (FAK)  Tubulin polymerization  Cancer cell lines  MDR  multidrug resistance  EGFR  epidermal growth factor receptor  EMEA  European Medicines Evaluation Agency  FDA  US Food and Drug Administration  NSCLC  non-small cell lung  FAK  focal adhesion kinase  RTK  receptor tyrosine kinases  MAPK  mitogen-activated protein kinase  ABC  ATP-binding cassette  NF-kB  NF-kappaB  FERM  Four-point-one, ezrin, radixin, moesin  TMP  Ligustrazine or tetramethylpyrazine  Adr  Adriamycin  DRS  death receptors  TFN  tumor necrosis factor  PI  propidium iodide  TKIs  tyrosine kinase inhibitors  FAR  fluorescence activity ratio  HRMS  high resolution mass spectra  TLC  thin layer chromatography  UV  ultraviolet  DMEM  Dulbecco's modified Eagle's medium  DMSO  dimethyl sulfoxide  IBX  2-iodoxybenzoic acid  
Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 373-385
作者:  Sun, Ying;  Shan, Yuanyuan;  Li, Chuansheng;  Si, Ru;  Pan, Xiaoyan
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26


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