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上海药物研究所 [11]
西安交通大学 [4]
西北高原生物研究所 [1]
中国科学院大学 [1]
海洋研究所 [1]
中南大学 [1]
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期刊论文 [22]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents
期刊论文
TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 40
作者:
Bai, Wenjing
;
Ji, Jianxin
;
Huang, Qiang
;
Wei, Wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/11/25
Thiourea derivatives
Antitumor
Antiangiogenesis
RTK inhibitors
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 15
作者:
Jin, Nan
;
Bi, Aiwei
;
Lan, Xiaojing
;
Xu, Jun
;
Wang, Xiaomin
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  |  
浏览/下载:60/0
  |  
提交时间:2020/07/01
Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs.
期刊论文
European journal of medicinal chemistry, 2019, 卷号: 164, 页码: 440-447
作者:
Shan Yuanyuan
;
Si Ru
;
Wang Jin
;
Zhang Qingqing
;
Zhou Huaxin
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  |  
浏览/下载:25/0
  |  
提交时间:2019/11/19
Anti-angiogenic agents
1,2,3-Triazole
RTK inhibitors
Multi-target
Compensatory activation
Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.
期刊论文
European journal of medicinal chemistry, 2019, 卷号: 163, 页码: 1-9
作者:
Pan Xiaoyan
;
Liang Liyuan
;
Si Ru
;
Wang Jin
;
Zhang Qingqing
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/11/19
Anti-angiogenic agents
Triple RTK inhibitors
1,2,3-Triazole
DFG-binding group
Multi-target
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 5003-5015
作者:
Song, Qiaoling
;
Sun, Xiaoxiao
;
Guo, Hui
;
Yu, Qiang
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
receptor tyrosine kinases
AKT
colorectal cancer
drug combination
RAS/RAF
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 135, 页码: 34-48
作者:
Zha, Gao-Feng
;
Qin, Hua-Li*
;
Youssif, Bahaa G. M.
;
Amjad, Muhammad Wahab
;
Raja, Maria Abdul Ghafoor
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/04
Epidermal growth factor receptor (EGFR)
BRAF
Focal adhesion kinase (FAK)
Tubulin polymerization
Cancer cell lines
MDR
multidrug resistance
EGFR
epidermal growth factor receptor
EMEA
European Medicines Evaluation Agency
FDA
US Food and Drug Administration
NSCLC
non-small cell lung
FAK
focal adhesion kinase
RTK
receptor tyrosine kinases
MAPK
mitogen-activated protein kinase
ABC
ATP-binding cassette
NF-kB
NF-kappaB
FERM
Four-point-one, ezrin, radixin, moesin
TMP
Ligustrazine or tetramethylpyrazine
Adr
Adriamycin
DRS
death receptors
TFN
tumor necrosis factor
PI
propidium iodide
TKIs
tyrosine kinase inhibitors
FAR
fluorescence activity ratio
HRMS
high resolution mass spectra
TLC
thin layer chromatography
UV
ultraviolet
DMEM
Dulbecco's modified Eagle's medium
DMSO
dimethyl sulfoxide
IBX
2-iodoxybenzoic acid
Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 373-385
作者:
Sun, Ying
;
Shan, Yuanyuan
;
Li, Chuansheng
;
Si, Ru
;
Pan, Xiaoyan
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/11/26
Hinge-binding group
1H-indazol-3-amine
Anti-angiogenesis agents
RTK inhibitors
Multi-target
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