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科研机构
海洋研究所 [3]
山东大学 [2]
自然资源部第一海洋研... [2]
上海药物研究所 [1]
青岛生物能源与过程研... [1]
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期刊论文 [9]
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2024 [1]
2020 [1]
2019 [2]
2017 [1]
2016 [4]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, fromRhodomela confervoides
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 卷号: 177, 期号: 19, 页码: 4464-4480
作者:
Luo, Jiao
;
Zheng, Meiling
;
Jiang, Bo
;
Li, Chao
;
Guo, Shuju
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2020/09/29
bromophenol
PTP1B inhibitor
selectivity
cell permeability
oral bioavailability
Nanotechnology-mediated immunochemotherapy with Ingenol-3-Mebutate for Systematic Anti-tumor Effects
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2019, 卷号: 304, 页码: 242-258
作者:
Yu, Mian
;
Zhao, Miaoqing
;
Yu, Rilei
;
Chu, Shaochen
;
Xu, Jiahao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/11
Ingenol-3-Mebutate
Immunotherapy
Nanoparticle
Small molecule drug
Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 735-751
作者:
Jin, Xin
;
Merrett, James
;
Tong, Sheng
;
Flower, Bartholomew
;
Xie, Jianling
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Mnk
eIF4E inhibition
Thieno[2,3-d]pyrimidine
Selective inhibitor
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 134, 页码: 24-33
作者:
Zhang, Renshuai
;
Yu, Rilei
;
Xu, Qi
;
Li, Xiangqian
;
Luo, Jiao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2017/07/10
PTP1B
Bromophenol
Saccharide
Selectivity
Permeability
Synthesis and Cytotoxicity against K562 Cells of 3-O-Angeloyl-20-O-acetyl Ingenol, a Derivative of Ingenol Mebutate
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 卷号: 17, 期号: 8
作者:
Liu, Ming
;
Chen, Fangling
;
Yu, Rilei
;
Zhang, Weiyi
;
Han, Mei
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/08/19
3-O-angeloyl-20-O-acetyl ingenol
PEP008
20-O-acetyl-ingenol-3-angelate
ingenol mebutat
apoptosis
chronic myeloid leukemia
Synthesis and Cytotoxicity against K562 Cells of 3-O-Angeloyl-20-O-acetyl Ingenol, a Derivative of Ingenol Mebutate
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 卷号: 17, 期号: 8
作者:
Liu, Ming
;
Chen, Fangling
;
Yu, Rilei
;
Zhang, Weiyi
;
Han, Mei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2018/12/07
3-O-angeloyl-20-O-acetyl ingenol
PEP008
20-O-acetyl-ingenol-3-angelate
ingenol mebutat
apoptosis
chronic myeloid leukemia
Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4
期刊论文
MOLECULAR PHARMACEUTICS, 2016, 卷号: 13, 期号: 5, 页码: 1699-1710
作者:
Yu, Zongjiang
;
Sun, Weizhi
;
Peng, Weibing
;
Yu, Rilei
;
Li, Guoqiang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2016/07/12
oleanolic acid (OA)
prodrug
hepatoprotective
pharmacokinetics
biodistribution
Synthesis and evaluation of novel non-covalent binding quinazoline glycoside derivatives targeting the L858R and T790M variants of EGFR
期刊论文
RSC ADVANCES, 2016, 卷号: 6, 期号: 43, 页码: 36857-36862
作者:
Zhang, Renshuai
;
Chen, Shaopeng
;
Zhang, Xiaowei
;
Yu, Rilei
;
Wan, Shengbiao
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
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