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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
期刊论文
FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12
作者:
Qi, Si-Min
;
Dong, Jinyun
;
Xu, Zhi-Yuan
;
Cheng, Xiang-Dong
;
Zhang, Wei-Dong
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  |  
浏览/下载:47/0
  |  
提交时间:2021/06/15
PROTAC
E3 ubiquitin ligase
protein degradation
ubiquitin-proteasome system
cancer therapy
Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 14
作者:
Zhao, Yanmei
;
Xu, Lei
;
Zhang, Jiankang
;
Zhang, Mengmeng
;
Lu, Jingyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Proteasome inhibitor
Piperidine
Peptidyl
Anti-cancer
SAR
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
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  |  
浏览/下载:21/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020
作者:
Yin, Yan-ping
;
Shi, Wen-hao
;
Deng, Ke
;
Liu, Xiao-li
;
Li, Hong
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  |  
浏览/下载:26/0
  |  
提交时间:2020/12/28
small cell lung cancer
obatoclax
bortezomib
carfilzomib
MCL-1
apoptosis
FOXM1
proteomics analysis
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Chen, Xiang-ling
;
Liu, Peng
;
Zhu, Wei-liang
;
Lou, Li-guang
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  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
DCZ5248
Hsp90
autophagy
lysosomal function
antitumor activity
colon cancer
Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells
期刊论文
ANTIOXIDANTS, 2019, 卷号: 8, 期号: 9
作者:
Lu, Xuxiu
;
Geng, Jiajia
;
Zhang, Jinman
;
Miao, Jinlai
;
Liu, Ming
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  |  
浏览/下载:30/0
  |  
提交时间:2019/10/29
K562
xanthohumol
BCR-ABL
degradation
autophagy
caspase
Xanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells
期刊论文
ANTIOXIDANTS, 2019, 卷号: 8, 期号: 9
作者:
Lu, Xuxiu
;
Geng, Jiajia
;
Zhang, Jinman
;
Miao, Jinlai
;
Liu, Ming
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/10/29
K562
xanthohumol
BCR-ABL
degradation
autophagy
caspase
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439
作者:
Yu, Jianjun
;
Liu, Jieyu
;
Li, Daqiang
;
Xu, Lei
;
Hong, Duidui
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Macrocyclic dipeptides
N-Benzyl amides
Metabolic stability
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