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CORC

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Pharmacology and anti-addiction effects of the novel kappa opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A 期刊论文
出版物, 3111, 期号: 0, 页码: 1-53
作者:  B Simonson;  A S Morani;  A W M Ewald;  L Walker;  N Kumar
收藏  |  浏览/下载：136/0  |  提交时间：2017/07/24
Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:  Wei, Yuan-yuan;  Ma, Yan;  Yao, Song-yu;  Kong, Ling-hui;  Liu, Xiao
收藏  |  浏览/下载：36/0  |  提交时间：2021/11/04
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:  He, Qian;  Wei, Yuanyuan;  Liu, Xiao;  Ye, Rongrong;  Kong, Linghui
收藏  |  浏览/下载：85/0  |  提交时间：2021/11/04
Amygdala dynorphin/kappa opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:  Zan, Gui-ying;  Sun, Xiang;  Wang, Yu-jun;  Liu, Rui;  Wang, Chen-yao
收藏  |  浏览/下载：22/0  |  提交时间：2021/08/17
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li
收藏  |  浏览/下载：110/0  |  提交时间：2021/05/24
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:  Huang, Huoming;  Wang, Wenli;  Xu, Xuejun;  Zhu, Chen;  Wang, Yujun
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载：89/0  |  提交时间：2020/07/01
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326
作者:  Wu, Jianhong;  Jiang, Qinghui;  Zhu, Hongwen;  Zhou, Yanting;  Lu, Dayun
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases 期刊论文
GLIA, 2019, 卷号: 67, 期号: 7, 页码: 1320-1332
作者:  Suo, Na;  Guo, Yu-e;  He, Bingqing;  Gu, Haifeng;  Xie, Xin
收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:  An, Xiaoli;  Bai, Qifeng;  Bing, Zhitong;  Zhou, Shuangyan;  Shi, Danfeng
收藏  |  浏览/下载：57/0  |  提交时间：2019/11/10

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