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浏览/检索结果: 共11条，第1-10条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma 期刊论文 CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218 作者:  Chen, Zi-qi;  Cao, Zhe-rui;  Wang, Yi;  Zhang, Xi;  Xu, Lan 收藏  |  浏览/下载：50/0  |  提交时间：2021/12/16 CYH33  MYC  P300  BET  B cell lymphoma  PI3K   Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells 期刊论文 CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13 作者:  Wang, Yu-xiang;  Zhang, Xu;  Ma, Qing-yang;  Hu, Lan-dian;  Zhang, Xi 收藏  |  浏览/下载：44/0  |  提交时间：2021/05/24 Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10 作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun 收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24 PI3K  Pyrrolo[2,1-f][1,2,4]triazine  Anti-cancer  Target therapy   PI3K alpha inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism 期刊论文 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9, 期号: 8, 页码: 16 作者:  Sun, Pu;  Zhang, Xi;  Wang, Rong-Jing;  Ma, Qing-Yang;  Xu, Lan 收藏  |  浏览/下载：41/0  |  提交时间：2021/11/04 tumor microenvironment  immunomodulation  immunologic memory  lymphocytes  tumor-infiltrating  macrophages   HRAS(G12s) mutant mediates resistance to a PI3K alpha inhibitor CYH33 in esophageal squamous cell carcinomas 期刊论文 MOLECULAR CANCER THERAPEUTICS, 2019, 卷号: 18, 期号: 12, 页码: 2 作者:  Wang, Yuxiang;  Zhang, Xu;  Ma, Qingyang;  Zhang, Xi;  Yang, Chunhao 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 PI3K alpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment 期刊论文 2019, 卷号: 459, 页码: 145-155 作者:  Shi, Jia-jie;  Xing, Hui;  Wang, Yu-xiang;  Zhang, Xi;  Zhan, Qi-min 收藏  |  浏览/下载：11/0  |  提交时间：2020/01/03 CYH33  Radiation  Synergism  ESCC  PI3K alpha   PI3K alpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment 期刊论文 CANCER LETTERS, 2019, 卷号: 459, 页码: 145-155 作者:  Shi, Jia-jie;  Xing, Hui;  Wang, Yu-xiang;  Zhang, Xi;  Zhan, Qi-min 收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 CYH33  Radiation  Synergism  ESCC  PI3K alpha   Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer 期刊论文 Cancer Biology and Medicine, 2019, 卷号: 16, 期号: 1, 页码: 66 作者:  Wang Yuxiang;  Li Xian;  Liu Xueling;  Chen Yi;  Yang Chunhao 收藏  |  浏览/下载：13/0  |  提交时间：2020/12/24 PI3Kα  CDK4/6  KRAS  NSCLC  CYH33   simultaneousinhibitionofpi3kandcdk46synergisticallysuppresseskrasmutatednonsmallcelllungcancer 期刊论文 癌症生物学与医学英文版, 2019, 卷号: 016, 期号: 001, 页码: 66 作者:  Yuxiang Wang;  Xian Li;  Xueling Liu;  Yi Chen;  Chunhao Yang 收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01 PI3Kα  CDK4/6  KRAS  NSCLC  CYH33   Discovery of clinical candidate methyl (5-(6-((4(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) : A highly potent and selective PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文 CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2 作者:  Xiang, Haoyue;  Wang, Xiang;  Chen, Yanhong;  Zhang, Xi;  Chen, Yi 收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01