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科研机构
四川大学 [2]
复旦大学上海医学院 [2]
湖南中医药大学 [2]
南华大学 [1]
西北高原生物研究所 [1]
大连化学物理研究所 [1]
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期刊论文 [13]
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分析化学与药物化学 [1]
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Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS
期刊论文
Journal of Pharmaceutical and Biomedical Analysis, 2018, 卷号: 150, 页码: 199-207
作者:
Chen, Man-Yun
;
Shao, Li
;
Zhang, Wei
;
Wang, Chong-Zhi
;
Zhou, Hong-Hao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/27
ACN
acetonitrile
DAD
diode array-detector
DMSO
dimethyl sulphoxide
ESI
electrospray ionization
GAM
general anaerobic medium
GF1
ginsenoside F1
GC-K
ginsenoside compound K
GRh2
ginsenoside Rh2
HF-HP
high-fat and high-protein
HPLC-DAD-Q-TOF-MS/MS
high-performance liquid chromatography coupled with diode array detection/quadrupole tandem time-of-flight mass spectrometry
LF-PF
low-fat and plant fiber-rich
LLE
liquid-liquid extraction
PPD
protopanaxadiol
PPT
protopanaxatriol
PNS
Panax notoginseng saponins
RSDs
relative standard deviations
SEM
standard deviation of mean
TICs
total ion chromatograms
Panax notoginseng
Ginsenosides
Gut microbiota
Biotransformation
Metabolic profile
HPLCDAD-Q-TOF-MS/MS
Detection of of 1,N-2-propano-2 '-deoxyguanosine adducts in genomic DNA by ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry in combination with stable isotope dilution
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2016, 卷号: 1450, 期号: 0, 页码: 38-44
作者:
Zhang, Ning
;
Song, Yuanyuan
;
Wu, Danni
;
Xu, Tian
;
Lu, Meiling
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2017/03/27
Crotonaldehyde (Cro)
1,N-2-propano-2'-deoxyguanosine adducts (ProdG adducts)
Ultrahigh performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A beta aggregation, and beta-secretase
期刊论文
Bioorganic and Medicinal Chemistry, 2014, 卷号: 22, 期号: 17, 页码: 4784-4791
作者:
Sun, Qi
;
Peng, Da-Yong
;
Yang, Sheng-Gang
;
Zhu, Xiao-Lei
;
Yang, Wen-Chao*
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
AD
Alzheimer’s disease
AChE
acetylcholinesterase
BChE
butylcholinesterase
ACh
acetylcholine
Aβ
amyloid-β
CAS
catalytic active site
PAS
peripheral active site
MD
molecular dynamics
ATC
acetylthiocholine
ESI-MS
electrospray ionisation mass spectrometry
DMF
dimethylformamide
DTNB
5′,5′-Dithio-bis(2-nitrobenzoic acid)
LGA
Lamarkian genetic algorithm
EDCI
1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
HOBt
N-hydroxybenzotriazole
PyBOP
benzotriazole-1-yl-oxytripyrrolidino-phosphonium hexafluorophosphate
Alzheimer’s disease
Coumarin
Acetylcholinesterase inhibitor
Butylcholinesterase inhibitor
Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller
期刊论文
Journal of Ethnopharmacology, 2014, 卷号: 152, 期号: 3, 页码: 470-477
作者:
Xie, Lian-Wu
;
Atanasov, Atanas G.
;
Guo, De-An
;
Malainer, Clemens
;
Zhang, Jing-Xian
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/28
1D NMR
one-dimensional nuclear magnetic resonance spectroscopy
2D NMR
two-dimensional nuclear magnetic resonance spectroscopy
ANOVA
analysis of variance
AP-1
activator protein 1
CC
column chromatography
CDCl3
deuterated chloroform
C/EBP
CCAAT/enhancer binding protein
CHCl3
chloroform
COSY
correlation spectroscopy in 2D NMR
DCM
dichloromethane
EGFP
enhanced green fluorescent protein
ESI-MS
electrospray ionization mass spectrometry
DMEM
Dulbecco׳s modified Eagle׳s medium
DMSO
dimethyl sulfoxide
EtOAc
ethyl acetate
EtOH
ethanol
FBS
fetal bovine serum
HEK293
human embryonic kidney 293
HMBC
heteronuclear multiple-bond correlation spectroscopy in 2D NMR
HPLC
high performance liquid chromatography
HSQC
heteronuclear single-quantum correlation spectroscopy in 2D NMR
IC50
half maximal inhibitory concentration
IκB
inhibitor of kappa B
IL-6
interleukin 6
IL-1β
interleukin-1 beta
MeOH
methanol
NF-κB
nuclear factor κB
NMR
nuclear magnetic resonance spectroscopy
PE
petroleum ether
PPARγ
peroxisome proliferator-activated receptor γ
TCM
traditional Chinese medicine
TLC
thin layer chromatography
TNF-α
tumor necrosis factor α
Trans-N-(p-coumaroyl)tyramine (PubChem CID: 5372945)
Trans-N-feruloyltyramine (PubChem CID: 5280537)
Trans-N-caffeoyltyramine (PubChem CID: 9994897)
Dihydro-N-caffeoyltyramine (PubChem CID: 16119668)
CHEMBL2337120 (PubChem CID: 71524307)
CHEMBL2337119 (PubChem CID: 71524308)
CHEMBL2337118 (PubChem CID: 71524309)
CHEMBL2337115 (PubChem CID: 71719510)
CHEMBL2337117 (PubChem CID: 71524310)
Lycium chinense Miller
Lycii Radicis Cortex
NF-κB
PPARγ
Phenolic amides
Fatty acids
Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller
期刊论文
Journal of Ethnopharmacology, 2014, 卷号: 152, 期号: 3, 页码: 470-477
作者:
Xie, Lian-Wu
;
Atanasov, Atanas G.
;
Guo, De-An
;
Malainer, Clemens
;
Zhang, Jing-Xian
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/27
1D NMR
one-dimensional nuclear magnetic resonance spectroscopy
2D NMR
two-dimensional nuclear magnetic resonance spectroscopy
ANOVA
analysis of variance
AP-1
activator protein 1
CC
column chromatography
CDCl3
deuterated chloroform
C/EBP
CCAAT/enhancer binding protein
CHCl3
chloroform
COSY
correlation spectroscopy in 2D NMR
DCM
dichloromethane
EGFP
enhanced green fluorescent protein
ESI-MS
electrospray ionization mass spectrometry
DMEM
Dulbecco׳s modified Eagle׳s medium
DMSO
dimethyl sulfoxide
EtOAc
ethyl acetate
EtOH
ethanol
FBS
fetal bovine serum
HEK293
human embryonic kidney 293
HMBC
heteronuclear multiple-bond correlation spectroscopy in 2D NMR
HPLC
high performance liquid chromatography
HSQC
heteronuclear single-quantum correlation spectroscopy in 2D NMR
IC50
half maximal inhibitory concentration
IκB
inhibitor of kappa B
IL-6
interleukin 6
IL-1β
interleukin-1 beta
MeOH
methanol
NF-κB
nuclear factor κB
NMR
nuclear magnetic resonance spectroscopy
PE
petroleum ether
PPARγ
peroxisome proliferator-activated receptor γ
TCM
traditional Chinese medicine
TLC
thin layer chromatography
TNF-α
tumor necrosis factor α
Trans-N-(p-coumaroyl)tyramine (PubChem CID: 5372945)
Trans-N-feruloyltyramine (PubChem CID: 5280537)
Trans-N-caffeoyltyramine (PubChem CID: 9994897)
Dihydro-N-caffeoyltyramine (PubChem CID: 16119668)
CHEMBL2337120 (PubChem CID: 71524307)
CHEMBL2337119 (PubChem CID: 71524308)
CHEMBL2337118 (PubChem CID: 71524309)
CHEMBL2337115 (PubChem CID: 71719510)
CHEMBL2337117 (PubChem CID: 71524310)
Lycium chinense Miller
Lycii Radicis Cortex
NF-κB
PPARγ
Phenolic amides
Fatty acids
SDS-PAGE-free protocol for comprehensive identification of cytochrome P450 enzymes and uridine diphosphoglucuronosyl transferases in human liver microsomes
期刊论文
proteomics, 2012, 卷号: 12, 期号: 23-24, 页码: 3464-3469
作者:
Sun, Liangliang
;
Zhang, Yanyan
;
Tao, Dingyin
;
Zhu, Guijie
;
Zhao, Qun
收藏
  |  
浏览/下载:84/0
  |  
提交时间:2015/11/13
1-Butyl-3-methyl imidazolium tetrafluoroborate
2D-LC-ESI-MS/MS
Cytochrome P450 enzyme
Protein spectral count
Uridine diphosphoglucuronosyl transferase
Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines
期刊论文
Journal of Proteomics, 2012, 卷号: 75, 期号: 8, 页码: 2352-2360
作者:
Tang, Sanyuan
;
Huang, Weiguo
;
Zhong, Meizuo*
;
Yin, Leilan
;
Jiang, Hao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/03
KRT1
NPC
cDDP
MDR
ESI-Q-TOF-MS
2-DE
Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines
期刊论文
Journal of Proteomics, 2012, 卷号: 75, 期号: 8, 页码: 2352-2360
作者:
Tang, Sanyuan
;
Huang, Weiguo
;
Zhong, Meizuo*
;
Yin, Leilan
;
Jiang, Hao
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/27
KRT1
NPC
cDDP
MDR
ESI-Q-TOF-MS
2-DE
Ultra-performance LC-photodiode array-el-ESI-MS/MS screening method for the detection of radical-scavenging natural antioxidants from Radix et Rhizoma Rhei
期刊论文
Journal of Separation Science, 2011, 卷号: 34, 页码: 268-277
作者:
Shi YP(师彦平)
;
Shi YP(师彦平)
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2012/10/18
Antioxidants
1-O-Galloyl-2-O-cinnamoylglucose
Radical-scavenging
Radix et Rhizoma Rhei
Ultra-performance LC-PDA-el-ESI-MS/MS
iTRAQ-2DLC-ESI-MS/MS Based Identification of a New Set of Immunohistochemical Biomarkers for Classification of Dysplastic Nodules and Small Hepatocellular Carcinoma
期刊论文
JOURNAL OF PROTEOME RESEARCH, 2011, 卷号: 10, 期号: 8
作者:
Jin, Guang-Zhi
;
Li, Yan
;
Cong, Wen-Ming
;
Yu, Hua
;
Dong, Hui
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/19
dysplastic nodules
small hepatocellular carcinoma
iTRAQ-2DLC-ESI-MS/MS
formalin-fixed and paraffin-embedded tissues
immunohistochemical marker
CD34
aminoacylase-1
sequestosome-1
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