transforming growth factor 1  osteoinduction  phosphatidylinositol 3-kinase  protein kinase B  mammalian target of rapamycin  S6 kinase 1  

Mammalian target of rapamycin (mTOR)  Orthosilicic acid  Osteoporosis  Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)  Protein kinase B (PKB/Akt)  

A1c  glycated hemoglobin  AACE  American Association of Clinical Endocrinologists  ACC  acetyl-CoA carboxylase  ADA  American Diabetes Association  Akt/PKB  tyrosine kinase/protein kinase B  AMP  adenosine monophosphate  AMPK  adenosine monophosphate-activated protein  Ang II  angiotensin II  ATP  adenosine triphosphate  BAT  brown adipose tissue  CHOP  CEBP-homologous protein  CEBP  CCAAT enhancer binding protein  CoA  coenzyme A  DPP  Diabetes Prevention Program  EASD  European Association for the Study of Diabetes  eNOS  endothelial nitric oxide synthase  ER  endoplasmic reticulum  FDA  Food and Drug Administration  FFA  free fatty acid  FOXO1  forkhead box protein O1  G6P  glucose 6-phosphate  GDM  gestational diabetes mellitus  GIPR  glucose-dependent insulinotropic polypeptide receptor  GLP-1R  glucagon-like peptide-1 receptor  GLUT1  glucose transporter-1  GLUT4  glucose transporter type 4  GLUTs  glucose transporters  G6P  glucose 6-phosphate, glucose transporter-1  GPR40  G protein-coupled receptor 40  HbA1c  hemoglobin A1c  HGP  hepatic glucose production  HSL  hormone sensitive lipase  IL-6  interleukin 6  INS-1  insulinoma cells in rat  IR  insulin resistance  IRS-1  insulin receptor substrate 1  JNK  c-Jun. N-terminal kinase  Kir6.2  inwardly rectifying potassium/kalium channel  LDs  lipid droplets  LDL  low density lipoprotein  LV  left ventricular  MIN6 cells  mouse insulinoma cells  MAPK  mitogen-activated protein kinases  mPTP  mitochondrial permeability transition pore opening  mTOR  mammalian target of rapamycin  NADPH  nicotinamide adenine dinucleotide phosphate  NF-kappaB  nuclear factors-kappa B  NIT-1 cells  insulinoma cells  p70S6K  p70 ribosomal S6 kinase  PA  palmitic acid  NOS  NADPH oxidase  p38 MAPK  p38 mitogen-activated protein kinase  PA  palmitic acid  PCOS  polycystic ovary syndrome  PGC-1α  peroxisome proliferator-activated receptor-g coactivator-1α  PI3K  phosphatidylinositol 3-kinase  PKB  protein kinase B  PKC  protein kinase C  PPARα  peroxisome-proliferator activated receptor α  PTP  permeability transition pore  RCT  randomized controlled trial  RISK  reperfusion injury salvage kinase  ROS  reactive oxygen species  SERCA2  reticulum sarcoplasmic Ca2 +-ATPase  RISK  reperfusion injury salvage kinase  Smad3  mothers against decapentaplegic homolog 3  SRC-2  steroid receptor coactivator 2  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TGFβ1  transforming growth factor β1  TLR4  Toll-like receptor  TNF-α  tumor necrosis factor α  TR4  testicular receptor 4  UKPDS  United Kingdom Prospective Diabetes Study  VLDL  very low density lipoprotein  Metformin  Pancreatic β Cells  Heart failure  Insulin sensitizer  

Phosphatidylinositol 3-kinase (PI3K)  genetic analysis  hematological malignancies  mammalian target of rapamycin (mTOR)  protein kinase B (Akt)  

OS  osteosarcoma  miRNAs  microRNAs  CSCs  cancer stem cells  RNA pol  RNA polymerase  DGCR8  DiGeorge syndrome critical gene 8  RISC  RNA-induced silencing complex  Exp 5  exportin 5  Ago  argonaute  MREs  miRNA recognition elements  APE1  apurinic/apyrimidinic endonuclease 1  MDM  murine double minute  TP53  tumor suppressor p53  mTOR  mammalian target of rapamycin  Eag1  ether à go-go 1  PI3K  phosphatidylinositol-3-kinase  PTEN  phosphatase and tensin homolog deleted on chromosome ten  Hsp90B1  heat shock protein 90B1  BMP2  bone morphogenetic protein 2  IGF1R  insulin-like growth factor 1 receptor  FAK  phospho-Akt and focal adhesion kinase  LPAATβ  lysophosphatidic acid acyltransferase β  HMGB1  high-mobility group box 1  FASN  fatty acid synthase  LZTS1  leucine zipper putative tumor suppressor 1  MMP  matrix metalloproteinase  LNA  locked nucleic acid  DATS  diallyl trisulfide  miRNAs  OS  TP53  Notch  Chemoresistance