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上海药物研究所 [34]
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期刊论文 [67]
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Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
收藏
  |  
浏览/下载:114/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326
作者:
Wu, Jianhong
;
Jiang, Qinghui
;
Zhu, Hongwen
;
Zhou, Yanting
;
Lu, Dayun
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Dimethyl labeling
Kappa-opioid receptor
Kinase-substrate network
p21-activated kinases
Quantitative phosphoproteomics
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
;
Shi, Danfeng
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  |  
浏览/下载:57/0
  |  
提交时间:2019/11/10
kappa-opioid receptor
Gaussian accelerated molecular dynamics simulation
agonist
antagonist
conformational change
Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a kappa Partial Agonist and mu Partial Agonist
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8
作者:
Wang, Yu-Hua
;
Chai, Jing-Rui
;
Xu, Xue-Jun
;
Ye, Ru-Feng
;
Zan, Gui-Ying
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  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14, 页码: 4254-4263
作者:
Sun, Hui-jiao
;
Wang, Yu-hua
;
Yuan, Cong-min
;
Kong, Ling-hui
;
Xu, Xue-jun
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  |  
浏览/下载:80/0
  |  
提交时间:2019/01/08
7 beta-Methyl-nepenthone analogues
KOR ligands
Concept of hybridization
Opioid receptor binding and functional activities
Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 3, 页码: 482-491
作者:
Cheng, Jian-xin
;
Cheng, Tao
;
Li, Wei-hua
;
Liu, Gui-xia
;
Zhu, Wei-liang
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
G-protein-coupled receptors
opioid receptors
subtype selectivity
molecular dynamics
"message-address-efficacy" hypothesis
JDTic
Genetic association analyses and meta-analysis of Dynorphin-Kappa Opioid system potential functional variants with heroin dependence.
期刊论文
Neuroscience letters, 2018, 卷号: 685, 页码: 75-82
作者:
Yuanyuan Ji
;
Rui Su
;
Hua Tang
;
Jingjing Cui
;
Cuola Deji
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  |  
浏览/下载:6/0
  |  
提交时间:2019/11/26
Heroin dependence
Prodynorphin
Single-nucleotide polymorphisms
k-Opioid receptors
Immunohistochemical identification of dynorphin A and Kappa opioid receptor-1 in the digestive system of scallop Chlamys farreri
期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2018, 卷号: 36, 期号: 6, 页码: 2288-2296
作者:
Sun Hushan
;
Wang Yiyan
;
Liu Xiaoli
;
Liu Dcmgwu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Chlamys farreri
dynorphin
digestive system
kappa opioid receptors
immunohistochemistry
GPCR Activation and Endocytosis Induced by a 2D Material Agonist
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 17, 页码: 14709-14715
作者:
Dou, Wei-Tao
;
Kong, Ya
;
He, Xiao-Peng
;
Chen, Guo-Rong
;
Zang, Yi
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
2D material
G protein-coupled receptor
ligand
peptide
fluorescence
imaging
photodynamic therapy
endocytosis
Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons
期刊论文
PAIN, 2017, 卷号: 158, 期号: 6
作者:
Sun, Linlin
;
Zhao, Jian-Yuan
;
Gu, Xiyao
;
Liang, Lingli
;
Wu, Shaogen
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
DNA methyltransferase 3a
Mu-opioid receptor
Kappa-opioid receptor
MBD1
Dorsal root ganglion
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