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山东大学 [4]
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学位论文 [2]
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Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Microcystin-LR induces dysfunction of insulin secretion in rat insulinoma (INS-1) cells: Implications for diabetes mellitus
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2016, 卷号: 314, 期号: 0, 页码: 11-21
作者:
Zhao, Yanyan
;
Shi, Kun
;
Su, Xiaomei
;
Xie, Liqiang
;
Yan, Yunjun
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2017/07/20
AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic beta-cell Apoptosis via Differential Downstream Mechanisms
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2015, 卷号: 11, 期号: 11, 页码: 1272-1280
作者:
Dai, Yu-Lu
;
Huang, Su-Ling
;
Leng, Ying
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
AICAR
Metformin
AMPK
INS-1E cells
apoptosis
Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells
期刊论文
http://dx.doi.org/10.1038/cddis.2012.206, 2013
Lin, Y.
;
Sun, X.
;
Qiu, L.
;
Wei, J.
;
Huang, Q.
;
Fang, C.
;
Ye, T.
;
Kang, M.
;
Shen, H.
;
Dong, S.
;
魏杰
;
黄琦
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
PANCREATIC BETA-CELLS
DIABETES-MELLITUS
LABORATORY ABNORMALITIES
URINARY
MECHANISMS
DEATH
ASSOCIATION
RESISTANCE
OBESITY
ADULTS
Autophagy induced by glibenclamide serves as a defense against apoptosis in INS-1 rat insulinoma cells
期刊论文
Journal of Diabetes Mellitus, 2013, 期号: 3, 页码: 122-128
作者:
Hua Su
;
Xingyan Liu
;
Ling Su
;
Li Zhang
;
Xiangguo Liu
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/23
Identification of a small molecule activator of novel PKCs for promoting glucose-dependent insulin secretion
期刊论文
CELL RESEARCH, 2011, 卷号: 21, 期号: 4, 页码: 588-599
作者:
Han, S
;
Pan, HL
;
Zhang, JH
;
Tan, L
;
Ma, DW
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/07/22
PKC
insulin secretion
glucose dependency
Golgi
Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways
期刊论文
ENDOCRINE, 2011, 卷号: 39, 期号: [db:dc_citation_issue], 页码: 128-138
作者:
Tuo, Ya
;
Wang, Dengfeng
;
Li, Shengbin
;
Chen, Chen
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/10
Linoleic acid
beta-Cell dysfunction
INS-1 beta cells
Mitochondrial
Apoptosis
无权访问的条目
学位论文
作者:
赵丽韵
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2015/10/16
无权访问的条目
学位论文
作者:
杨柳
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2015/10/16
无权访问的条目
期刊论文
作者:
Yang, Liu(杨柳)
;
Zhao, Liyun
;
Gan, Zhenji
;
He, Zixuan
;
Xu, Jingyue
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2015/10/12
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