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上海药物研究所 [6]
中国科学院大学 [4]
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期刊论文 [16]
学位论文 [2]
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Crystal structure determination of a chimeric FabF by XRD
期刊论文
NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 9
作者:
Li, Ke
;
Li, Li
;
Xu, Ye-Chun
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
FabF
Chimera
X-ray diffraction
Crystal structure determination
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
crystalstructuredeterminationofachimericfabfbyxrd
期刊论文
nuclearscienceandtechniques, 2017, 卷号: 028, 期号: 009, 页码: 123
作者:
Li Ke
;
Li Li
;
Xu Yechun
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
晶体结构
嵌合体
XRD
广谱抗菌活性
测定
药物设计
生产菌株
PTM
Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis
期刊论文
CELL RESEARCH, 2016, 卷号: 26, 期号: 12, 页码: 1330-1344
作者:
Zhang, Lin
;
Xiao, Jianfeng
;
Xu, Jianrong
;
Fu, Tianran
;
Cao, Zhiwei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
fatty acid biosynthesis
dehydratase
ACP
complex structure
A new strategy for strain improvement of Aurantiochytrium sp based on heavy-ions mutagenesis and synergistic effects of cold stress and inhibitors of enoyl-ACP reductase
期刊论文
ENZYME AND MICROBIAL TECHNOLOGY, 2016, 卷号: 93-94, 页码: 182-190
作者:
Cheng Yu-rong
;
Sun Zhi-jie
;
Cui Gu-zhen
;
Song Xiaojin
;
Cui Qiu
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2017/01/03
Aurantiochytrium sp.
Heavy-ions mutagenesis
Triclosan
Isoniazid
Coldstress
Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein
期刊论文
CHEMICAL SCIENCE, 2016, 卷号: 7, 期号: 3, 页码: 1779-1785
作者:
Dong, Xu
;
Bailey, Christopher D.
;
Williams, Christopher
;
Crosby, John
;
Simpson, Thomas J.
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2016/05/03
以微拟球藻为模式的微藻产油功能基因组学研究
学位论文
博士, 北京: 中国科学院研究生院, 2013
作者:
李敬
收藏
  |  
浏览/下载:250/0
  |  
提交时间:2013/07/13
生物燃料
微拟球藻
功能基因组学
脂组
基因组
转录组
模式体系
Isolation and characterization of an enoyl-acyl carrier protein reductase gene from microalga Isochrysis galbana
期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2013, 卷号: 31, 期号: 2, 页码: 398-406
作者:
Zheng Minggang
;
Liang Kepeng
;
Wang Bo
;
Sun Xiuqin
;
Yue Yanyan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/08/19
Isochrysis galbana
enoyl-ACP reductase
real-time quantitative PCR
temperature
nitrogen
Isolation and characterization of an enoyl-acyl carrier protein reductase gene from microalga Isochrysis galbana
期刊论文
CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2013, 卷号: 31, 期号: 2, 页码: 398-406
作者:
Zheng Minggang
;
Liang Kepeng
;
Wang Bo
;
Sun Xiuqin
;
Yue Yanyan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2018/12/07
Isochrysis galbana
enoyl-ACP reductase
real-time quantitative PCR
temperature
nitrogen
Role and Regulation of Fatty Acid Biosynthesis in the Response of Shewanella piezotolerans WP3 to Different Temperatures and Pressures
期刊论文
http://dx.doi.org/10.1128/JB.00498-08, 2009
Wang, Feng
;
Xiao, Xiang
;
Ou, Hong-Yu
;
Gai, Yingbao
;
Wang, Fengping
;
王峰
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
DEEP-SEA BACTERIUM
CARRIER PROTEIN SYNTHASE
BRANCHED-CHAIN
SP-NOV.
ESCHERICHIA-COLI
MEMBRANE-LIPIDS
ANTIBIOTIC CERULENIN
GROWTH TEMPERATURE
ONEIDENSIS MR-1
STRAIN SS9
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