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上海药物研究所 [50]
复旦大学上海医学院 [11]
兰州大学 [8]
合肥物质科学研究院 [8]
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湖南大学 [7]
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期刊论文 [196]
学位论文 [4]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Complete genome analysis of pathogenic Metschnikowia bicuspidata strain MQ2101 isolated from diseased ridgetail white prawn, Exopalaemon carinicauda
期刊论文
BMC MICROBIOLOGY, 2023, 卷号: 23, 期号: 1, 页码: 17
作者:
Shi, Wen-jun
;
Zhao, Ran
;
Zhu, Jian-qiang
;
Wan, Xi-he
;
Wang, Li-bao
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/11/15
Exopalaemon carinicauda
Metschnikowia bicuspidata
Complete genome sequence
Virulence genes
Metabolic mechanism
Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors
期刊论文
BMC Medicine, 2022, 卷号: 20, 期号: 1
作者:
Zhang,Pei
;
Du,Yang
;
Bai,Hua
;
Wang,Zhijie
;
Duan,Jianchun
收藏
  |  
浏览/下载:123/0
  |  
提交时间:2022/11/21
Tucidinostat
Tumor microenvironment
PD-L1
CCL5
Solid tumor
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
Prevalence and Correlates of Anxiety and Depressive Symptoms in Patients With and Without Multi-Drug Resistant Pulmonary Tuberculosis in China
期刊论文
FRONTIERS IN PSYCHIATRY, 2021, 卷号: 12, 页码: 7
作者:
Liu, Kewei
;
Zhang, Yidan
;
Qu, Shilin
;
Yang, Wenying
;
Guo, Liyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/10/29
tuberculosis
TB stigma
social supports
depression
anxiety
drug-resistant
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge
期刊论文
PLOS COMPUTATIONAL BIOLOGY, 2021, 卷号: 17, 期号: 9, 页码: 19
作者:
Xiong, Zhaoping
;
Jeon, Minji
;
Allaway, Robert J.
;
Kang, Jaewoo
;
Park, Donghyeon
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/11/04
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:
Lu, Tingting
;
Cao, Jiangyan
;
Zou, Fengming
;
Li, Xixiang
;
Wang, Aoli
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/04/26
BCR-ABL
ABL mutants
Chronic myeloid leukemia
Kinase inhibitor
Imatinib resistance
Functional characterization, antimicrobial effects, and potential antibacterial mechanisms of new mastoparan peptides from hornet venom (Vespa ducalis, Vespa mandarinia, and Vespa affinis)
期刊论文
TOXICON, 2021, 卷号: 200, 期号: x, 页码: 48-54
作者:
Wen, Xinxin
;
Gongpan, Pianchou
;
Meng, Yichuan
;
Nieh, James C.
;
Yuan, Hongling
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/10/21
Antimicrobial peptides
Drug-resistance
alpha-helical structure
Amphiphilic
Antibiotic
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
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