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浏览/检索结果: 共7条，第1-7条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299 作者:  Huang, Huoming;  Li, Xinwei;  Guo, Wei;  Zhu, Chen;  Qian, Yuanyuan 收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24 pain  opioid analgesic  SAR  selective MOR agonist  molecular dynamics simulations   Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14 作者:  Huang, Huoming;  Wang, Wenli;  Xu, Xuejun;  Zhu, Chen;  Wang, Yujun 收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 Selective MOR agonists  Antinociception  Analgesic  Opioids  Molecular mechanism   Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326 作者:  Wu, Jianhong;  Jiang, Qinghui;  Zhu, Hongwen;  Zhou, Yanting;  Lu, Dayun 收藏  |  浏览/下载：40/0  |  提交时间：2020/07/01 Dimethyl labeling  Kappa-opioid receptor  Kinase-substrate network  p21-activated kinases  Quantitative phosphoproteomics   How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584 作者:  An, Xiaoli;  Bai, Qifeng;  Bing, Zhitong;  Zhou, Shuangyan;  Shi, Danfeng 收藏  |  浏览/下载：57/0  |  提交时间：2019/11/10 kappa-opioid receptor  Gaussian accelerated molecular dynamics simulation  agonist  antagonist  conformational change   7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14, 页码: 4254-4263 作者:  Sun, Hui-jiao;  Wang, Yu-hua;  Yuan, Cong-min;  Kong, Ling-hui;  Xu, Xue-jun 收藏  |  浏览/下载：79/0  |  提交时间：2019/01/08 7 beta-Methyl-nepenthone analogues  KOR ligands  Concept of hybridization  Opioid receptor binding and functional activities   7 beta-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 14 作者:  Sun, Hui-jiao;  Wang, Yu-hua;  Yuan, Cong-min;  Kong, Ling-hui;  Xu, Xue-jun 收藏  |  浏览/下载：11/0  |  提交时间：2019/12/05 7 beta-Methyl-nepenthone analogues  KOR ligands  Concept of hybridization  Opioid receptor binding and functional activities   Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination 期刊论文 NATURE COMMUNICATIONS, 2016, 卷号: 7 作者:  Du, Changsheng;  Duan, Yanhui;  Wei, Wei;  Cai, Yingying;  Chai, Hui 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08