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Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
Structures of the glucocorticoid-bound adhesion receptor GPR97-G(o) complex
期刊论文
NATURE, 2021, 页码: 35
作者:
Ping, Yu-Qi
;
Mao, Chunyou
;
Xiao, Peng
;
Zhao, Ru-Jia
;
Jiang, Yi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet beta Cells via G Protein-Coupled Receptor 40
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2020, 卷号: 54, 期号: 6, 页码: 3428-3436
作者:
Qin, Wei-Ping
;
Cao, Lin-Ying
;
Li, Chuan-Hai
;
Guo, Liang-Hong
;
Colbourne, John
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  |  
浏览/下载:21/0
  |  
提交时间:2021/09/14
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice
期刊论文
JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214
作者:
Du, Te
;
Yang, Liu
;
Xu, Xu
;
Shi, Xiaofan
;
Xu, Xin
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  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
vincamine
GPR40
beta-cell function
insulin secretion
type 2 diabetes
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 2
作者:
Colin-Lozano, Blanca
;
Estrada-Soto, Samuel
;
Chavez-Silva, Fabiola
;
Gutierrez-Hernandez, Abraham
;
Ceron-Romero, Litzia
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
diabetes
GPR40
AKRB1
PPAR gamma
GLUT-4
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
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  |  
浏览/下载:37/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Structural Studies of G Protein-Coupled Receptors
期刊论文
IUBMB LIFE, 2016, 卷号: 68, 期号: 11, 页码: 894-903
作者:
Lu, Mengjie
;
Wu, Beili
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
G protein-coupled receptor
structural studies
chemokine receptor
purinergic receptor
Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry
期刊论文
BIOCHEMISTRY, 2016, 卷号: 55, 期号: 13, 页码: 1989-1996
作者:
Ren, Xiao-Min
;
Cao, Lin-Ying
;
Zhang, Jing
;
Qin, Wei-Ping
;
Yang, Yu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2017/03/27
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists
期刊论文
CHINESE CHEMICAL LETTERS, 2016, 卷号: 27, 期号: 1, 页码: 159-162
作者:
Huang, Jing
;
Guo, Bin
;
Chu, Wen-Jing
;
Xie, Xin
;
Yang, Yu-She
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
GPR40
Anti-diabetic
Agonist
Phenylpropionic acid derivative
Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury
期刊论文
Drug metabolism and disposition: the biological fate of chemicals, 2015, 卷号: 43, 期号: 11, 页码: 1751-9
作者:
Li, Xiuli
;
Zhong, Kan
;
Guo, Zitao
;
Zhong, Dafang
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
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