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科研机构
上海药物研究所 [8]
大连化学物理研究所 [3]
合肥物质科学研究院 [2]
四川大学 [1]
内容类型
期刊论文 [14]
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2022 [2]
2021 [2]
2020 [2]
2019 [3]
2018 [2]
2017 [2]
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BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer
期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:
Lv, Yang
;
Lv, Xiaotong
;
Zhang, Jiahui
;
Cao, Guozhen
;
Xu, Changzhi
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/05/16
small cell lung cancer
BRD4
KEAP1
Nrf2
pentose phosphate pathway
Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma
期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:
Chen, Zi-qi
;
Cao, Zhe-rui
;
Wang, Yi
;
Zhang, Xi
;
Xu, Lan
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2021/12/16
CYH33
MYC
P300
BET
B cell lymphoma
PI3K
Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells
期刊论文
GENOMICS, 2021, 卷号: 113, 期号: 3, 页码: 1057-1069
作者:
Liu, Yuwei
;
Xue, Mengzhu
;
Cao, Danyan
;
Qin, Lihuai
;
Wang, Ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
Multi-omics
BET inhibitor responses
WNT pathway
Liver cancer
Precise therapy
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:
Wu, Qian
;
Chen, Dan-Qi
;
Sun, Lin
;
Huan, Xia-Juan
;
Bao, Xu-Bin
收藏
  |  
浏览/下载:115/0
  |  
提交时间:2021/05/24
N2817
Bivalent BET inhibitors
Monovalent BET inhibitors
TAF1
Anticancer activity
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction
期刊论文
INVESTIGATIONAL NEW DRUGS, 2020, 卷号: 38, 期号: 3, 页码: 700-713
作者:
Damaneh, Mohammadali Soleimani
;
Hu, Jian-Ping
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Tian, Chang-Qing
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
BET inhibitor
Cell proliferation
Apoptosis
Anti-cancer agent
A patent review of BRD4 inhibitors (2013-2019)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2020, 卷号: 30, 期号: 1, 页码: 57-81
作者:
Lu, Tian
;
Lu, Wenchao
;
Luo, Cheng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Bromodomain-containing protein 4 (BRD4)
bromodomain and extra-terminal (BET) family
small molecule inhibitors
cancer
patent
therapeutic potential
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine
期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13
作者:
Tian, Chang-Qing
;
Chen, Lin
;
Chen, Hua-Dong
;
Huan, Xia-Juan
;
Hu, Jian-Ping
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 卷号: 38, 页码: 15
作者:
Qin, Jianhua
;
Liu, Yang
;
Yin, Yalei
;
Sun, Mingju
;
Zhan, Xi
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2019/06/20
Bromodomain
JQ1
MAPK pathway
MYC
EGFR mutation
Sorafenib
Egfr signaling confers resistance to bet inhibition in hepatocellular carcinoma through stabilizing oncogenic myc
期刊论文
Journal of experimental & clinical cancer research, 2019, 卷号: 38, 页码: 15
作者:
Yin, Yalei
;
Sun, Mingju
;
Zhan, Xi
;
Wu, Changqing
;
Geng, Pengyu
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/05/08
Bromodomain
Jq1
Mapk pathway
Myc
Egfr mutation
Sorafenib
Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
作者:
Feng, Yuxin
;
Xiao, Senhao
;
Chen, Yantao
;
Jiang, Hao
;
Liu, Na
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
Benzo[cd]indol-2(1H)-one
Sulfonamide
BRD4 inhibitor
Bromodomain and extra-terminal domain
Acetyl-lysine binding pocket
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