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科研机构
上海药物研究所 [24]
内容类型
期刊论文 [24]
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2021 [3]
2020 [1]
2018 [6]
2014 [3]
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2011 [2]
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Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yong-zhen
;
Lu, Heng-lei
;
Qi, Xin-ming
;
Xing, Guo-zhen
;
Wang, Xin
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
aristolochic acid I
glutathione S-transferase placental form-positive foci
clonal expansion
hepatocellular carcinoma
medium-term rat liver bioassay
DNA adducts
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:
Yang, Li
;
Pei, Rong-juan
;
Li, Heng
;
Ma, Xin-na
;
Zhou, Yu
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/12/24
COVID-19
SARS-CoV-2
virus entry inhibitors
high throughput screening assay
approved drug library
histamine receptor antagonists
clemastine
AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness
期刊论文
Developmental cell, 2018
作者:
Wang, Xinbo
;
Jin, Jiali
;
Wan, Fangning
;
Zhao, Linlin
;
Chu, Hongshang
收藏
  |  
浏览/下载:182/0
  |  
提交时间:2019/01/08
Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 10, 页码: 1633-1644
作者:
Yan, Yu-xi
;
Shao, Mei-juan
;
Qi, Qing
;
Xu, Yan-sheng
;
Yang, Xiao-qian
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
SM934
artemisinin analogue
ulcerative colitis
inflammatory bowel disease (IBD)
neutrophils macrophage
NF-kappa B
RAW 2647 cells
THP-1-derived macrophages
Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2018, 卷号: 16, 期号: 5, 页码: 358-365
作者:
Jiang Cheng-Shi
;
Zhou Zhen-Fang
;
Yang Xiao-Hong
;
Lan Le-Fu
;
Gu Yu-Cheng
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Mangrove
Penicillium sp.
Sorbicillin derivative
Diketopiperazine alkaloids
Facile Synthesis of New Functionalized Triazacyclopenta[cd]indenones Through a Multicomponent Reaction Followed by an Intramolecular Aminolysis
期刊论文
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 卷号: 55, 期号: 4, 页码: 814-820
作者:
Shen, Guo-Bing
;
Yu, Ting
;
Zhang, Yong-Liang
;
Ma, Lan-Ping
;
Chen, Lin
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice
期刊论文
Frontiers in pharmacology, 2018, 卷号: 9, 页码: 346
作者:
Li, Shu-Ping
;
Wang, Yu-Wen
;
Qi, Sheng-Lan
;
Zhang, Yun-Peng
;
Deng, Gang
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
(5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fc gamma receptor signaling
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 1, 页码: 107-116
作者:
Qi, Qing
;
Li, Heng
;
Lin, Ze-min
;
Yang, Xiao-qian
;
Zhu, Feng-hua
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
triptolide
(5R)-5-hydroxytriptolide (LLDT-8)
prednisolone
glomerulonephritis
immune complexes
inflammation
Fc gamma receptor signaling
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