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上海药物研究所 [9]
吉林大学白求恩第一医... [8]
合肥物质科学研究院 [7]
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期刊论文 [38]
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药物化学 [2]
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Zanubrutinib monotherapy for relapsed or refractory non-germinal center diffuse large B-cell lymphoma
期刊论文
BLOOD ADVANCES, 2022, 卷号: 6
作者:
Yang, Haiyan
;
Xiang, Bing
;
Song, Yuqin
;
Zhang, Huilai
;
Zhao, Weili
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/12/23
Bruton's tyrosine kinase inhibitors in primary central nervous system lymphoma-evaluation of anti-tumor efficacy and brain distribution
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2021, 卷号: 10
作者:
Yu, Haifeng
;
Kong, Haiying
;
Li, Cong
;
Dong, Xiaowu
;
Wu, Yizhe
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/08/31
Primary central nervous system lymphoma ( PCNSL)
Bruton's tyrosine kinase (BTK)
ibrutinib
zanubrutinib
tirabrutinib
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190, 页码: 14
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
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  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton's tyrosine kinase inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 415-422
作者:
Lai, Meng-zhen
;
Song, Pei-ran
;
Dou, Dou
;
Diao, Yan-yan
;
Tong, Lin-jiang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
B cell receptor
Bruton's tyrosine kinase
ibrutinib
small-molecule inhibitor
B cell malignancies
Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
Synthesis and biological evaluation of novel 1-substituted 3-(3-phenoxyprop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amines as potent Bruton's tyrosine kinase (BTK) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 2
作者:
Zheng, Nan
;
Hao, Qun
;
Lin, Kuaile
;
Pan, Jing
;
Li, Yingxia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
BTK inhibitors
1-Substituted pyrazolo[3,4-d]pyrimidine
Inhibitory activity
B-cell lymphoblastic leukemia
Cytotoxicity
Discovery of novel pyrazole derivatives as potential anticancer agents in MCL
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 9, 页码: 1060-1064
作者:
Ran, Fansheng
;
Liu, Yang
;
Zhang, Daoguang
;
Liu, Meixia
;
Zhao, Guisen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/12/11
Mantle cell lymphoma
BTK
Irreversible inhibitors
Anticancer
Pyrazole
derivatives
Discovery of pyrazolopyrimidine derivatives as potent BTK inhibitors with effective anticancer activity in MCL
期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 89
作者:
Ran, Fansheng
;
Liu, Yang
;
Liu, Meixia
;
Zhang, Daoguang
;
Wang, Peng
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Mantle cell lymphoma
BTK inhibitors
Anticancer
Selectivity
Patient
cells
Molecular modelling studies on cinnoline-based BTK inhibitors using docking and structure-based 3D-QSAR
期刊论文
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2018, 卷号: 29, 期号: 11, 页码: 847-873
作者:
Li, R.
;
Du, Y.
;
Shen, J.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
BTK inhibitors
B-cell malignancies
molecule docking
3D-QSAR
CoMFA
CoMSIA
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