Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza

doi:10.1016/S1875-5364(18)30068-2

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza
	Jiang Cheng-Shi 1,2; Zhou Zhen-Fang 1; Yang Xiao-Hong 3; Lan Le-Fu1 ; Gu Yu-Cheng 4; Ye Bo-Ping 3; Guo Yue-Wei1
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2018-05
卷号	16 期号:5 页码:358-365
关键词	Mangrove Penicillium sp. Sorbicillin derivative Diketopiperazine alkaloids
ISSN号	2095-6975
DOI	10.1016/S1875-5364(18)30068-2
文献子类	Article
英文摘要	One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 mu g.mL(-1).
资助项目	Natural Science Foundation of China[81520108028] ; SCTSM Projects[14431901100] ; SCTSM Projects[15431901000] ; SKLDR/SIMM Project[SIMM1501ZZ-03]
WOS关键词	ANALOGS ; INHIBITORS ; DESIGN
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:6247462
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000433996500006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279770]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第三研究室
通讯作者	Ye Bo-Ping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, China State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; 3.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China; 4.Syngenta Jealotts Hill Int Res Ctr, Warfield RG42 6EY, Berks, England
推荐引用方式 GB/T 7714	Jiang Cheng-Shi,Zhou Zhen-Fang,Yang Xiao-Hong,et al. Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2018,16(5):358-365.
APA	Jiang Cheng-Shi.,Zhou Zhen-Fang.,Yang Xiao-Hong.,Lan Le-Fu.,Gu Yu-Cheng.,...&Guo Yue-Wei.(2018).Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza.CHINESE JOURNAL OF NATURAL MEDICINES,16(5),358-365.
MLA	Jiang Cheng-Shi,et al."Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp GD6 associated Chinese mangrove Bruguiera gymnorrhiza".CHINESE JOURNAL OF NATURAL MEDICINES 16.5(2018):358-365.