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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [11]
会议论文 [1]
发表日期
2021 [3]
2020 [1]
2019 [2]
2017 [1]
2015 [1]
2013 [1]
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Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:
Zhang, Ning
;
Tian, Yu-Nan
;
Zhou, Li-Na
;
Li, Meng-Zhu
;
Chen, Hua-Dong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1
作者:
Ning Zhang
;
Yu-Nan Tian
;
Li-Na Zhou
;
Meng-Zhu Li
;
Hua-Dong Chen
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/01
N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors.
期刊论文
CANCER IMMUNOLOGY RESEARCH, 2020, 卷号: 8, 期号: 3, 页码: 51-51
作者:
Chen, Shulun
;
Guo, Wei
;
Sun, Pu
;
Meng, Linghua
;
Zhang, Ao
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 179, 页码: 38-55
作者:
Chen, Shulun
;
Guo, Wei
;
Liu, Xiaohua
;
Sun, Pu
;
Wang, Yi
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Indoleamine 2,3-dioxygenase
Immunotherapy
Oxadiazole
PD-1
Life span
Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO-1) Inhibitors Based on Ortho-Naphthaquinone-Containing Natural Product
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 11
作者:
Zhao, Hongchuan
;
Sun, Pu
;
Guo, Wei
;
Wang, Yi
;
Zhang, Ao
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
indoleamine 2
3-dioxygenase 1
immunosuppressive
natural product
ortho-naphthaquinone
molecular docking
SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1156-1171
作者:
Wei, Manman
;
Zhang, Xi
;
Wang, Xiang
;
Song, Zilan
;
Ding, Jian
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Chronic lymphocytic leukemia
PI3K delta
Structure-activity relationship
5-Alkynyl
Quinazolinone
Targeting PI3K: Emerging Therapy for Chronic Lymphocytic Leukemia and Beyond
期刊论文
MEDICINAL RESEARCH REVIEWS, 2015, 卷号: 35, 期号: 4, 页码: 720-752
作者:
Wei, Manman
;
Wang, Xiang
;
Song, Zilan
;
Jiao, Mingkun
;
Ding, Jian
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
chronic lymphocytic leukemia
PI3K
inhibitor
molecularly targeted therapy
idelalisib
Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity
期刊论文
NEW JOURNAL OF CHEMISTRY, 2013, 卷号: 37, 期号: 6, 页码: 1817-1822
作者:
Wu, Meng
;
Wang, Zi-Wen
;
Liu, Yu-Xiu
;
Song, Hai-Bin
;
Zhang, Ao
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 51, 页码: 250-258
作者:
Wang, Ziwen
;
Wu, Meng
;
Wang, Yi
;
Li, Zheng
;
Wang, Lei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Phenanthroindolizidine
Phenanthroquinolizidine
14-Amino-derivative
A549
HL60
Anti-tumor activity
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